膳食多酚或能用于肠道和神经慢性疾病的营养治疗(综述)

肠道失调不仅与肠道疾病有关,还可经肠-脑轴参与帕金森症、阿尔茨海默症、自闭症等神经疾病的进展;
膳食多酚主要来自水果、蔬菜、谷物、茶、咖啡和红酒等,有抗氧化功能;
可局部作用于肠道,抑制促炎症相关细胞信号通路(NF-κB和JAK/STAT等)、调节肠道菌群,从而改善慢性肠道疾病;
也可直接作用于大脑,减少神经炎症和氧化应激,增加海马区神经发生和脑血流量以改善记忆和认知功能,还可经肠脑轴间接改善神经疾病。
延伸阅读

Dietary polyphenols: A novel strategy to modulate microbiota-gut-brain axis

膳食多酚:调节菌群-肠-脑轴的新策略

2018-06-19, Review, 10.1016/j.tifs.2018.06.007more

Abstract:
Background Although great advances have been made in the discovery of new drugs that effectively penetrate the brain and alleviate neurological disorders, such as Alzheimer's disease, Parkinson's disease and Autism Spectrum Disorder, current pharmacological treatment options are unable to eradicate these diseases. The growing awareness of a bidirectional communication between the brain and the intestinal compartment, with particular focus on the role played by the gut microbiota in the gut-brain binomial, has opened new avenues for the investigation of the molecular mechanisms underlying those neurological diseases and, consequently, for the discovery of a new generation of disease-modifying strategies. Scope and approach We present an overview of the evidence supporting the importance of dysbiosis in the development of intestinal and neurological diseases. In addition, the usefulness of dietary polyphenols in managing disorders, via modulation of the microbiota-gut-brain axis, is discussed. Key findings and conclusions Dietary polyphenols are increasingly envisaged as a novel and a relevant strategy in the prevention and treatment of neurological disorders. This is explained not only by their ability to reduce neuroinflammation and to improve memory and cognitive function, but also by their ability to modulate the gut microbiota, which makes them promising nutraceuticals to combat brain disorders.

First Authors:
Diana Serra

Correspondence Authors:
Diana Serra

All Authors:
Diana Serra,Leonor M Almeida,Teresa CP Dinis