杯状细胞在粘膜免疫中的作用(综述)

杯状细胞是位于粘膜表面的特化上皮细胞,可分泌黏液维持肠道屏障功能,限制肠道菌群的易位;
另外,杯状细胞可分泌抗菌肽、趋化因子、细胞因子等,在先天性免疫中发挥作用;
同时,杯状细胞可形成杯状细胞相关抗原通道(GAP),将肠道内腔中的物质递送给固有层中的抗原呈递细胞,GAP的形成不仅局限于肠道,也存在于身体其它部位的粘膜表面中;
在小肠、远端结肠、近端结肠中,存在着不同的GAP调节机制。
延伸阅读
Mucosal Immunology [IF:7.36]

Goblet cells: multifaceted players in immunity at mucosal surfaces

杯状细胞:粘膜表面免疫中的多面手

2018-06-04, Review, 10.1038/s41385-018-0039-ymore

Abstract:
Goblet cells (GCs) are specialized epithelial cells that line multiple mucosal surfaces and have a well-appreciated role in barrier maintenance through the secretion of mucus. Moreover, GCs secrete anti-microbial proteins, chemokines, and cytokines demonstrating functions in innate immunity beyond barrier maintenance. Recently it was appreciated that GCs can form goblet cell-associated antigen passages (GAPs) and deliver luminal substances to underlying lamina propria (LP) antigen-presenting cells (APCs) in a manner capable of inducing adaptive immune responses. GCs at other mucosal surfaces share characteristics with the GAP forming intestinal GCs, suggesting that GAP formation may not be restricted to the gut, and that GCs may perform this gatekeeper function at other mucosal surfaces. Here we review observations of how GCs contribute to immunity at mucosal surfaces through barrier maintenance, the delivery of luminal substances to APCs, interactions with APCs, and secretion of factors modulating immune responses.

First Authors:
Kathryn A Knoop

Correspondence Authors:
Kathryn A Knoop

All Authors:
Kathryn A Knoop,Rodney D Newberry