Cell子刊:婴儿的菌群发育,母亲的直接贡献很大

对25对母婴的多个身体部位进行纵向取样,分析婴儿出生后4个月内的口腔和肠道菌群的来源和母亲菌群纵向传递的作用;
婴儿出生时随机定殖大量来自母亲不同部位的微生物,随后,所处部位的生理环境对菌群进行强力选择,使菌群多样性先快速下降、后逐渐上升;
种和株水平的分析表明,来自母亲的微生物持续地传递给婴儿,婴儿的肠道菌群和口腔菌群与母亲同部位菌群的相似度随时间增加;
母亲向婴儿传递的菌株主要来自肠道菌群。
延伸阅读
Cell Host and Microbe [IF:17.872]

Mother-to-Infant Microbial Transmission from Different Body Sites Shapes the Developing Infant Gut Microbiome

来自不同身体部位的母婴微生物传播塑造发育中的婴儿肠道菌群

2018-07-11, Article, 10.1016/j.chom.2018.06.005more

Abstract:
The acquisition and development of the infant microbiome are key to establishing a healthy host-microbiome symbiosis. The maternal microbial reservoir is thought to play a crucial role in this process. However, the source and transmission routes of the infant pioneering microbes are poorly understood. To address this, we longitudinally sampled the microbiome of 25 mother-infant pairs across multiple body sites from birth up to 4 months postpartum. Strain-level metagenomic profiling showed a rapid influx of microbes at birth followed by strong selection during the first few days of life. Maternal skin and vaginal strains colonize only transiently, and the infant continues to acquire microbes from distinct maternal sources after birth. Maternal gut strains proved more persistent in the infant gut and ecologically better adapted than those acquired from other sources. Together, these data describe the mother-to-infant microbiome transmission routes that are integral in the development of the infant microbiome.

First Authors:
Edoardo Pasolli,Adrian Tett,Francesco Asnicar

Correspondence Authors:
Nicola Segata

All Authors:
Pamela Ferretti,Edoardo Pasolli,Adrian Tett,Francesco Asnicar,Valentina Gorfer,Sabina Fedi,Federica Armanini,Duy Tin Truong,Serena Manara,Moreno Zolfo,Francesco Beghini,Roberto Bertorelli,Veronica De Sanctis,Ilaria Bariletti,Rosarita Canto,Rosanna Clementi,Marina Cologna,Tiziana Crifò,Giuseppina Cusumano,Stefania Gottardi,Claudia Innamorati,Caterina Masè,Daniela Postai,Daniela Savoi,Sabrina Duranti,Gabriele Andrea Lugli,Leonardo Mancabelli,Francesca Turroni,Chiara Ferrario,Christian Milani,Marta Mangifesta,Rosaria Anzalone,Alice Viappiani,Moran Yassour,Hera Vlamakis,Ramnik Xavier,Carmen Maria Collado,Omry Koren,Saverio Tateo,Massimo Soffiati,Anna Pedrotti,Marco Ventura,Curtis Huttenhower,Peer Bork,Nicola Segata