Cell子刊:孩子继承母亲的肠道细菌有什么规律?

在44对母婴中,分析婴儿出生头3个月的肠道菌群动态,纵向评估母亲向婴儿传递肠道细菌的模式;
对某个菌种而言,多数情况下,孩子会继承母亲的优势菌株,但次要菌株的传递也时有发生;
次要菌株的定殖似乎是由功能选择所驱动,比如:当母亲的单形拟杆菌的主要菌株缺乏促进代谢母乳的淀粉利用基因时,具有该基因的次要菌株可在孩子肠道内定殖;
母亲菌群中的抗生素耐药基因也会传递给孩子。
延伸阅读
Cell Host and Microbe [IF:17.872]

Strain-Level Analysis of Mother-to-Child Bacterial Transmission during the First Few Months of Life

在菌株水平分析出生后前几个月母亲向孩子的细菌传递

2018-07-11, Article, 10.1016/j.chom.2018.06.007more

Abstract:
Bacterial community acquisition in the infant gut impacts immune education and disease susceptibility. We compared bacterial strains across and within families in a prospective birth cohort of 44 infants and their mothers, sampled longitudinally in the first months of each child's life. We identified mother-to-child bacterial transmission events and describe the incidence of family-specific antibiotic resistance genes. We observed two inheritance patterns across multiple species, where often the mother's dominant strain is transmitted to the child, but occasionally her secondary strains colonize the infant gut. In families where the secondary strain of B. uniformis was inherited, a starch utilization gene cluster that was absent in the mother's dominant strain was identified in the child, suggesting the selective advantage of a mother's secondary strain in the infant gut. Our findings reveal mother-to-child bacterial transmission events at high resolution and give insights into early colonization of the infant gut.

First Authors:
Moran Yassour,Eeva Jason,Larson J Hogstrom

Correspondence Authors:
Moran Yassour,Ramnik J Xavier

All Authors:
Moran Yassour,Eeva Jason,Larson J Hogstrom,Timothy D Arthur,Surya Tripathi,Heli Siljander,Jenni Selvenius,Sami Oikarinen,Heikki Hyöty,Suvi M Virtanen,Jorma Ilonen,Pamela Ferretti,Edoardo Pasolli,Adrian Tett,Francesco Asnicar,Nicola Segata,Hera Vlamakis,Eric S Lander,Curtis Huttenhower,Mikael Knip,Ramnik J Xavier