Nature Reviews:iNKT细胞在不同组织中的功能(综述)

创作:张玲 审核:李丹宜 2018年07月12日

Tissue-specific functions of invariant natural killer T cells


2018-07-02, Review, 10.1038/s41577-018-0034-2more

Invariant natural killer T cells (iNKT cells) are an innate-like T cell subset that expresses an invariant T cell receptor (TCR) α-chain and recognizes lipids presented on CD1d. They secrete diverse cytokines and can influence many types of immune responses. Despite having highly similar TCR specificities, iNKT cells differentiate in the thymus into distinct subsets that are analogous to T helper 1 (T1), T2 and T17 cell subsets. Additional iNKT cell subsets that may require peripheral activation have also been described, including one that produces IL-10. In general, iNKT cells are non-circulating, tissue-resident lymphocytes, but the prevalence of different iNKT cell subsets differs markedly between tissues. Here, we summarize the functions of iNKT cells in four tissues in which they are prevalent, namely, the liver, the lungs, adipose tissue and the intestine. Importantly, we explain how local iNKT cell responses at each site contribute to tissue homeostasis and protection from infection but can also contribute to tissue inflammation and damage.

First Authors:
Catherine M Crosby

Correspondence Authors:
Mitchell Kronenberg

All Authors:
Catherine M Crosby,Mitchell Kronenberg