Nature Reviews:iNKT细胞在不同组织中的功能(综述)

创作:张玲 审核:李丹宜 2018年07月12日
恒定自然杀伤T细胞(iNKT)为类先天性T细胞亚群,表达恒定T细胞受体(TCR)α链,可被细胞因子和CD1d提呈的抗原活化;
iNKT可在胸腺和外周分化为NKT1、2、17、FH、10等不同亚群,类似于辅助T细胞亚群和ILC亚群,分泌不同的细胞因子,影响多种免疫应答;
不同组织驻留的iNKT亚群不同,功能有所差异;
在脂肪内诱导白色脂肪棕色化、调控代谢,在肠道内与菌群互作,在肝、肺等组织内维持组织稳态、防御感染,亦参与组织炎症和损伤。
延伸阅读

Tissue-specific functions of invariant natural killer T cells

恒定自然杀伤T细胞的组织特异性功能

2018-07-02, Review, 10.1038/s41577-018-0034-2more

Abstract:
Invariant natural killer T cells (iNKT cells) are an innate-like T cell subset that expresses an invariant T cell receptor (TCR) α-chain and recognizes lipids presented on CD1d. They secrete diverse cytokines and can influence many types of immune responses. Despite having highly similar TCR specificities, iNKT cells differentiate in the thymus into distinct subsets that are analogous to T helper 1 (T1), T2 and T17 cell subsets. Additional iNKT cell subsets that may require peripheral activation have also been described, including one that produces IL-10. In general, iNKT cells are non-circulating, tissue-resident lymphocytes, but the prevalence of different iNKT cell subsets differs markedly between tissues. Here, we summarize the functions of iNKT cells in four tissues in which they are prevalent, namely, the liver, the lungs, adipose tissue and the intestine. Importantly, we explain how local iNKT cell responses at each site contribute to tissue homeostasis and protection from infection but can also contribute to tissue inflammation and damage.

First Authors:
Catherine M Crosby

Correspondence Authors:
Mitchell Kronenberg

All Authors:
Catherine M Crosby,Mitchell Kronenberg