Nature子刊:自身免疫病中的Treg(综述)

创作:张玲 审核:李丹宜 2018年07月12日
调节性T细胞(Treg)的正常功能需要转录因子Foxp3的高表达和特定的表观遗传特征;
多种自身免疫性疾病中存在Treg异常:Foxp3表达缺失导致细胞不稳定(Treg不稳定性;ex-Foxp3),或者Treg表观遗传特征改变(Treg可塑性)从而获得辅助性T细胞功能(TH1、2、17样Treg);
组织驻留Treg执行非免疫功能,维持组织稳态和修复创伤,也可能参与器官特异的自身免疫病;
肌肉、皮肤、肺、肠、肝和脂肪等组织中的Treg具有组织特异的表型和功能。
延伸阅读
Nature Immunology [IF:21.809]

Regulatory T cells in autoimmune disease

调节性T细胞在自身免疫性疾病中的作用

2018-06-20, Review, 10.1038/s41590-018-0120-4more

Abstract:
In recent years, the understanding of regulatory T cell (T cell) biology has expanded considerably. Key observations have challenged the traditional definition of T cells and have provided insight into the underlying mechanisms responsible for the development of autoimmune diseases, with new therapeutic strategies that improve disease outcome. This Review summarizes the newer concepts of T cell instability, T cell plasticity and tissue-specific T cells, and their relationship to autoimmunity. Those three main concepts have changed the understanding of T cell biology: how they interact with other immune and non-immune cells; their functions in specific tissues; and the implications of this for the pathogenesis of autoimmune diseases.

First Authors:
Margarita Dominguez-Villar

Correspondence Authors:
Margarita Dominguez-Villar,David A Hafler

All Authors:
Margarita Dominguez-Villar,David A Hafler