Science:调控菌群稳态,肠道生理状态很重要(综述)
创作:mildbreeze 审核:mildbreeze 08月01日
  • 宿主通过控制肠腔内的电子受体(如氧和硝酸盐)可用性来塑造菌群组成,例如在大肠中,宿主通过维持肠上皮细胞的生理性缺氧来限制肠腔氧浓度,从而选择专性厌氧菌;
  • 在宿主对菌群控制力正常时,尽管不同饮食(如哺乳vs成人饮食)塑造的菌群组成有很大差异,这些菌群都处于稳态;
  • 然而,不良饮食、抗生素和肠道疾病等因素会削弱宿主对菌群的控制力,使肠腔氧含量增加,驱动了菌群失调和有害代谢物生成;
  • 对控制菌群生长的宿主参数(如肠腔氧浓度)进行量化,可帮助定义菌群的稳态和失调,而恢复宿主对菌群的控制可作为改善菌群失调的新策略。
主编推荐语
mildbreeze
肠道菌群组成的变化与许多人类疾病息息相关。然而,到目前为止,人们还难以基于特定微生物物种的存在或缺失来准确定义菌群的稳态或失调。Science本周发表的美国加州大学戴维斯分校Andreas J Bäumler团队的综述则提出,除了饮食对肠道菌群的影响外,宿主生理因素(特别是肠腔内的电子受体水平)也是调控肠道菌群组成和功能的一个重要驱动力,为定义和干预菌群失调提供了新视角。
关键字
延伸阅读本研究的原文信息和链接出处,以及相关解读和评论文章。欢迎读者朋友们推荐!
图片
Science [IF:63.714]

The microbiome and gut homeostasis

微生物组与肠道稳态

10.1126/science.abp9960

06-30, Article

Abstract & Authors:展开

Abstract:收起
Changes in the composition of the gut microbiota are associated with many human diseases. So far, however, we have failed to define homeostasis or dysbiosis by the presence or absence of specific microbial species. The composition and function of the adult gut microbiota is governed by diet and host factors that regulate and direct microbial growth. The host delivers oxygen and nitrate to the lumen of the small intestine, which selects for bacteria that use respiration for energy production. In the colon, by contrast, the host limits the availability of oxygen and nitrate, which results in a bacterial community that specializes in fermentation for growth. Although diet influences microbiota composition, a poor diet weakens host control mechanisms that regulate the microbiota. Hence, quantifying host parameters that control microbial growth could help define homeostasis or dysbiosis and could offer alternative strategies to remediate dysbiosis.

First Authors:
Jee-Yon Lee

Correspondence Authors:
Andreas J Bäumler

All Authors:
Jee-Yon Lee,Renée M Tsolis,Andreas J Bäumler

评论