一图读懂:吃东西上瘾?脑-肠-菌群轴出了啥问题(综述)
创作:orchid 审核:兵兵 09月09日
  • 饮食行为不规律导致肥胖或食物成瘾,伴随着脑-肠-菌群(BGM)轴的改变,且改变后的BGM互作机制具有一定的稳定性;
  • 膳食和菌群互作、其对饱腹和肠道炎症的介导以及由此对脑稳态相关机制的扰乱,导致对进食的享乐回馈机制和抑制机制产生重大影响;
  • 上述机制会反过来进一步刺激机体对高热量食物的选择,恶化肠道失调;
  • 靶向BGM多节点的治疗方法的结合,以及基于肠道菌群组成和功能的个体干预,可能是未来缓解肥胖或食物成瘾的可取方式。
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这篇发表在Nature Reviews Gastroenterology and Hepatology上的综述文章,重点研究了肥胖或食物成瘾状态下,脑肠轴的相互作用和调节机制。膳食与菌群互作产生的信号分子,影响奖赏和抑制等调节机制,进而反过来影响机体膳食选择。环境因素,比如压力、抗生素等也会影响BGM。除了减肥手术,基于BGM的干预手段,比如限时饮食、认知行为干预等,可能也是防疗肥胖和食物成瘾的方式。我们特别将配图翻译制作了一图读懂,希望能帮你涨知识。
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Brain–gut–microbiome interactions in obesity and food addiction

肥胖和食物成瘾中脑-肠-菌群的相互作用

10.1038/s41575-020-0341-5

08-27, Review

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Normal eating behaviour is coordinated by the tightly regulated balance between intestinal and extra-intestinal homeostatic and hedonic mechanisms. By contrast, food addiction is a complex, maladaptive eating behaviour that reflects alterations in brain–gut–microbiome (BGM) interactions and a shift of this balance towards hedonic mechanisms. Each component of the BGM axis has been implicated in the development of food addiction, with both brain to gut and gut to brain signalling playing a role. Early-life influences can prime the infant gut microbiome and brain for food addiction, which might be further reinforced by increased antibiotic usage and dietary patterns throughout adulthood. The ubiquitous availability and marketing of inexpensive, highly palatable and calorie-dense food can further shift this balance towards hedonic eating through both central (disruptions in dopaminergic signalling) and intestinal (vagal afferent function, metabolic endotoxaemia, systemic immune activation, changes to gut microbiome and metabolome) mechanisms. In this Review, we propose a systems biology model of BGM interactions, which incorporates published reports on food addiction, and provides novel insights into treatment targets aimed at each level of the BGM axis.

First Authors:
Arpana Gupta

Correspondence Authors:
Emeran A Mayer

All Authors:
Arpana Gupta,Vadim Osadchiy,Emeran A Mayer

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