英国大队列:母亲吸烟对后代肥胖的影响很长远
  • 纳入英国24万余名数据库人员信息,根据97个BMI相关基因多态性计算遗传风险评分(PGS);
  • 根据出生体重(低/正常/高)和成年期BMI(非肥胖/肥胖)划分为6类体重生长模式;
  • 母亲吸烟者出生体重平均低0.108kg,但成年期体重平均高出1.418kg;
  • 母亲吸烟者后代体重增长模式为“低出生体重-成年期肥胖”的风险增高1.98倍;
  • 母亲吸烟与PGS评分存在交互作用,母亲吸烟可修饰PGS基因易感性,从而改变其对出生/成年期体重的影响。
主编推荐语
小笋干儿
本研究结果提示,母亲吸烟者儿童出生体重更低,但未来发生肥胖的风险也更高,呈现“低出生体重-成年期肥胖”的体重变化模式。并且母亲吸烟还与肥胖相关基因易感性存在交互作用。该研究强调了吸烟对后代儿童长期不良作用。
关键字
延伸阅读本研究的原文信息和链接出处,以及相关解读和评论文章。欢迎读者朋友们推荐!

Maternal smoking, genetic susceptibility, and birth-to-adulthood body weight

母亲吸烟、基因易感性及后代出生到成年体重变化规律

10.1038/s41366-019-0509-7

2019-12-19, Article

Abstract & Authors:展开

Abstract:收起
Background: Maternal smoking (MS) is associated with low birthweight (BW) but adult obesity in offspring, however, it remains unknown whether it modifies offspring’s genetic susceptibility to obesity on BW, adult body weight, and birth-to-adulthood body weight tracking pattern.
Methods: This study included 246,759 UK Biobank participants with information on MS, BW (kg), adult body weight and BMI (kg/m2). Individual polygenetic score (PGS) was created on the basis of 97 BMI-associated genetic loci. We calculated individual birth-to-adulthood percentile change, and body weight tracking patterns that combined BW levels (<2.5, 2.5–4.0, and ≥4.0 as low, normal and high BW [LBW, NBW, and HBW]) and adulthood obesity status (≥30 as obesity [OB] and <30 as non-obesity [NOB]), including LBW-to-OB, LBW-to-NOB, NBW-to-OB, NBW-to-NOB, HBW-to-OB, and HBW-to-NOB.
Results: Participants exposed to MS had a 0.108 kg lower BW (95% CI, −0.114 to −0.102), a 1.418 kg higher adult body weight (95% CI, 1.291–1.545), and a 6.91 greater percentile increase of body weight from birth to adulthood (95% CI, 6.62–7.21), compared with those nonexposed (all P < 0.001). In comparison to participants of NBW-to-NOB, MS was associated with an approximately twofold higher risk of LBW-to-OB (odds ratio [OR] 1.98, 95% CI 1.87–2.10), and a reduced likelihood of HBW-to-NOB (0.85, 95% CI 0.82–0.88). The increases in BW, adult body weight, and birth-to-adulthood percentile change per increment of 10 BMI-PGS were 0.021 vs. 0.012, 2.50 vs. 2.11, and 4.03 vs. 3.55, respectively, for participants exposed vs. nonexposed to MS (all Pinteraction < 0.05).
Conclusion: Our results indicate that exposure to MS is associated with an increased risk of transition from low BW-to-adulthood obesity, and reduced likelihood of change from high BW-to-normal adult body weight. MS may modify the relation of genetic susceptibility to obesity and body weight in offspring.

First Authors:
Dianjianyi Sun

Correspondence Authors:
Lu Qi

All Authors:
Dianjianyi Sun,Tao Zhou,Xiang Li,Sylvia H Ley,Yoriko Heianza,Lu Qi

评论