Nature子刊:抗生素和住院治疗对早产儿肠道菌群有长期影响
  • 用宏基因组测序技术分析58名婴儿出生后21个月内的437份粪便样品;
  • 在前一个月里接受一个以上抗生素疗程的婴儿肠道菌群多样性显著降低,而早产儿的菌群虽然有短期的发育延迟,但21个月后接近未使用抗生素的健康婴儿菌群;
  • 生命早期接受抗生素治疗对极早产儿肠道菌群的长期影响包括:富含耐药基因、携带多重耐药肠杆菌科、具有独特的抗生素驱动的菌群模式和耐药组;
  • 早期抗生素和住院治疗对早产儿的副作用是长期的,需寻找应对方案。
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mildbreeze
早产儿易患感染性疾病,因此在出生后的住院期间,通常会接受较多的抗生素治疗。这些因素对早产儿肠道菌群以及菌群的抗生素耐药性有何长期影响?Nature Microbiology近期的一项研究,通过宏基因组学、细菌分离培养和机器学习等分析手段,对这一问题进行了深入研究。
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Persistent metagenomic signatures of early-life hospitalization and antibiotic treatment in the infant gut microbiota and resistome

生命早期住院治疗和抗生素治疗的婴儿肠道菌群和耐药组的持续的宏基因组学特征

10.1038/s41564-019-0550-2

2019-09-09, Article

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Hospitalized preterm infants receive frequent and often prolonged exposures to antibiotics because they are vulnerable to infection. It is not known whether the short-term effects of antibiotics on the preterm infant gut microbiota and resistome persist after discharge from neonatal intensive care units. Here, we use complementary metagenomic, culture-based and machine learning techniques to study the gut microbiota and resistome of antibiotic-exposed preterm infants during and after hospitalization, and we compare these readouts to antibiotic-naive healthy infants sampled synchronously. We find a persistently enriched gastrointestinal antibiotic resistome, prolonged carriage of multidrug-resistant Enterobacteriaceae and distinct antibiotic-driven patterns of microbiota and resistome assembly in extremely preterm infants that received early-life antibiotics. The collateral damage of early-life antibiotic treatment and hospitalization in preterm infants is long lasting. We urge the development of strategies to reduce these consequences in highly vulnerable neonatal populations.

First Authors:
Andrew J Gasparrini

Correspondence Authors:
Gautam Dantas

All Authors:
Andrew J Gasparrini,Bin Wang,Xiaoqing Sun,Elizabeth A Kennedy,Ariel Hernandez-Leyva,I Malick Ndao,Phillip I Tarr,Barbara B Warner,Gautam Dantas

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Nature Reviews Genetics期刊

Early-life antibiotic use and gut microbiota

Linda Koch,2019-09-13

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