与糖尿病和心血管疾病相关的血液菌群及其代谢物(综述)
  • 过量的微生物及细菌内毒物可通过肠道屏障进入血液循环,导致长期炎症并引起糖尿病和心血管疾病(CVD);
  • 病毒感染是儿童1型糖尿病风险因子,2型糖尿病患者血浆中球形梭菌和阿托波菌属等革兰氏阳性菌浓度高;
  • 金黄色葡萄球菌、大肠杆菌和克雷伯氏菌等致病菌感染是导致以中风为代表的心血管疾病的重要风险因子;
  • 血液循环中的菌群代谢物如短链脂肪酸、支链氨基酸及其衍生物和氧化三甲胺等均被发现与血糖和CVD相关,可作为未来药物靶点。
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Trends in Endocrinology & Metabolism的这篇文章总结了关于血液菌群及其代谢物与糖尿病和心血管疾病之间关系的研究。随着测序技术和代谢组学技术的发展,现在健康人血液中也检测出了以变形菌门为主的遗传物质,诸多菌群代谢物也被发现与与人体疾病的息息关系,菌群及其代谢物均有望成为糖尿病和心血管疾病的生物标记,并成为新的治疗靶点。
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Blood Microbiota and Circulating Microbial Metabolites in Diabetes and Cardiovascular Disease

与糖尿病和心血管疾病相关的血液菌群及其代谢物

10.1016/j.tem.2020.01.013

02-11, Review

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Diabetes and cardiovascular disease (CVD) have evolved as the leading cause of mortality and morbidity worldwide. In addition to traditional risk factors, recent studies have established that the human microbiota, particularly gut bacteria, plays a role in the development of diabetes and CVD. Although the presence of microbes in blood has been known for centuries, mounting evidence in this metagenomic era provides new insights into the role of the blood microbiota in the pathogenesis of non-infectious diseases such as diabetes and CVD. We highlight the origin and physiology of the blood microbiota and circulating microbial metabolites in relation to the etiology and progression of diabetes and CVD. We also discuss translational perspectives targeting the blood microbiota in the diagnosis and treatment of diabetes and CVD.

First Authors:
Ganesan Velmurugan

Correspondence Authors:
Ganesan Velmurugan

All Authors:
Ganesan Velmurugan,Vasudevan Dinakaran,Jeyaprakash Rajendhran,Krishnan Swaminathan

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