新生儿肠道菌群的发育与形成
创作:Vera 审核:Vera 02月19日
  • 采集了1303个出生后3月、6月、12月母乳喂养婴儿的粪便;
  • 3个月大时,婴儿的菌群组成较混杂,主要由双歧杆菌,拟杆菌,埃希氏杆菌组成;
  • 剖腹产生产的婴儿拟杆菌降低,同时,12月出现的过敏性皮炎和婴儿肠道内3月大的梭菌sensu stricto丰度升高相关;
  • 成年人特异菌群的富集以及向拟杆菌属的转型在出生后一年内即形成;
  • 过敏源干扰增加了婴儿肠道内的shannon多样性,同时增加了特定的菌群,例如普雷沃氏菌和变形菌门。
主编推荐语
Vera
肠道微生物在宿主早期免疫教育中可能发挥着重要作用,Journal of Allergy and Clinical Immunology上发表了一项研究,报道了婴儿肠道微生物群的发育,进化,以及与卫生相关的环境因素、特应性疾病和随机引入致敏固体后的组成变化,为临床提供更好的健康诊断和评估奠定了基础。
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Gut microbiota development during infancy: Impact of introducing allergenic foods

婴儿肠道菌群的发育:过敏源食物的影响

10.1016/j.jaci.2020.09.042

02-01, Article

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Background: The gut microbiota potentially plays an important role in the immunologic education of the host during early infancy.
Objective: We sought to determine how the infant gut microbiota evolve during infancy, particularly in relation to hygiene-related environmental factors, atopic disorders, and a randomized introduction of allergenic solids.
Methods: A total of 1303 exclusively breast-fed infants were enrolled in a dietary randomized controlled trial (Enquiring About Tolerance study) from 3 months of age. In this nested longitudinal study, fecal samples were collected at baseline, with additional sampling of selected cases and controls at 6 and 12 months to study the evolution of their gut microbiota, using 16S ribosomal RNA gene-targeted amplicon sequencing.
Results: In the 288 baseline samples from exclusively breast-fed infant at 3 months, the gut microbiota was highly heterogeneous, forming 3 distinct clusters: Bifidobacterium-rich, Bacteroides-rich, and Escherichia/Shigella-rich. Mode of delivery was the major discriminating factor. Increased Clostridium sensu stricto relative abundance at 3 months was associated with presence of atopic dermatitis on examination at age 3 and 12 months. From the selected cases and controls with longitudinal samples (n = 70), transition to Bacteroides-rich communities and influx of adult-specific microbes were observed during the first year of life. The introduction of allergenic solids promoted a significant increase in Shannon diversity and representation of specific microbes, such as genera belonging to Prevotellaceae and Proteobacteria (eg, Escherichia/Shigella), as compared with infants recommended to exclusively breast-feed.
Conclusions: Specific gut microbiota characteristics of samples from 3-month-old breast-fed infants were associated with cesarean birth, and greater Clostridium sensu stricto abundance was associated with atopic dermatitis. The randomized introduction of allergenic solids from age 3 months alongside breast-feeding was associated with differential dynamics of maturation of the gut microbial communities.

First Authors:
Tom Marrs,Jay-Hyun Jo

Correspondence Authors:
Heidi H Kong,Carsten Flohr

All Authors:
Tom Marrs,Jay-Hyun Jo,Michael R Perkin,Damian W Rivett,Adam A Witney,Kenneth D Bruce,Kirsty Logan,Joanna Craven,Suzana Radulovic,Serge A Versteeg,Ronald van Ree,W H Irwin McLean,David P Strachan,Gideon Lack,Heidi H Kong,Carsten Flohr

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