益生菌和合生制剂干预对炎症标志物的影响
创作:迟卉 审核:mildbreeze 2019年06月02日
  • 纳入167项口服益生菌/合生制剂一周以上的对照临床试验,对其对炎症标志物的影响进行系统回顾和荟萃分析;
  • 分析的炎症标志物包括:C-反应蛋白(CRP)、白介素(IL)1β、IL-4、IL-6、IL-8、IL-10、IL-12、肿瘤坏死因子α(TNF-α)、干扰素γ(IFNγ)和转化生长因子β(TGFβ);
  • 益生菌/合生制剂干预可降低部分炎症标志物水平,对健康或疾病状态下CRP和TNF-α的影响尤其明显;
  • 对减少炎症性肠病、关节炎和脂肪肝的炎症最有效。
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mildbreeze
《Clinical Nutrition》近期发表一项研究,对167项临床试验进行荟萃分析,表明益生菌/合生制剂干预可降低部分炎症标志物水平(特别是CRP和TNF-α),对炎症性肠病、关节炎和脂肪肝的炎症改善效果较好。
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Effect of Probiotic and Synbiotic Supplementation on Inflammatory Markers in Health and Disease Status: A Systematic Review and Meta-analysis of Clinical Trials

益生菌和合生制剂补充对健康和疾病状态下的炎症标志物的影响:临床试验的系统回顾和Meta分析

10.1016/j.clnu.2019.04.004

2019-04-17, Article

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The current systematic review and meta-analysis investigated the effect of probiotic/synbiotic on a wide range of inflammatory and anti-inflammatory markers in healthy and various disease conditions. PubMed, SCOPUS and Web of Science databases were searched. All clinical trials which investigated the effect of oral administration of probiotic or synbiotic on inflammatory markers (C-reactive protein (CRP), interleukin (IL) 1β, IL-4, IL-6, IL-8, IL-10, IL-12, tumor necrosis factor (TNF) α, interferon (IFN) γ and transforming growth factor (TGF) β) for more than one week with concurrent control groups were included. One-hundred sixty seven publications was analysed. Results were as follows: CRP decreased in healthy, metabolic disorders, inflammatory bowel disease (IBD), arthritis and critically ill condition but not in renal failure. IL-1B: no change in healthy subjects and arthritis. TNF-α: decreased in healthy, fatty liver, IBD and hepatic cirrhosis, no change in diabetes, metabolic syndrome (MS) + PCOS (polycystic ovary syndrome) and arthritis. IL-6: no change in healthy, metabolic disorders and arthritis, increased in cirrhosis and renal failure, decreased in PCOS + MS. IL-10: no change in healthy, IBD and metabolic disorders, increased in arthritis. IL-4, IL-8, IL-12, IFN-g and TGF-b: no change in healthy subjects. In conclusion, probiotic/synbiotic decreased some of the inflammatory markers. The intervention was most effective in CRP and TNF-α reduction in healthy or disease state. Moreover, the intervention decreased inflammation most effectively in the following disease conditions, respectively: IBD, arthritis, fatty liver.

First Authors:
Asma Kazemi

Correspondence Authors:
Seyed Mohammad Mazloomi

All Authors:
Asma Kazemi,Sepideh Soltani,Sima Ghorabi,Abbas Keshtkar,Elnaz Daneshzad,Fatemeh Nasri,Seyed Mohammad Mazloomi

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