肥胖相关的自控缺陷,可能是肠道菌群出了问题
创作:lzm 审核:mildbreeze 03月01日
  • 肠道菌群组成/功能和血液/粪便代谢组,都与人的抑制控制(IC)能力相关;
  • 鉴定出菌群和代谢组的一碳代谢、色氨酸和组氨酸通路与IC相关,但这些关联受肥胖状态的影响;
  • 肠道菌群还与调控IC的大脑结构存在关联;
  • 肥胖者的IC缺陷能通过粪菌移植在小鼠中复现部分相关表型,影响逆转学习(反映认知灵活性)和大脑转录组;
  • 这些发现提示,调节肠道菌群或能改善肥胖相关的冲动行为(IC缺陷),对改善肥胖者的健康饮食依从性或有重要意义。
主编推荐语
mildbreeze
抑制控制(IC)是指个体抑制住自己的冲动、本能的认知过程,能帮助个体达成长期目标,是对自身行为控制力的一种体现。肥胖者通常存在IC缺陷,因而难以抵挡美食的诱惑或者难以坚持锻炼,使得减肥变得困难重重。Gut近期发表的一项研究,结合临床分析和小鼠试验,鉴定出肠道菌群和代谢组等与IC之间的潜在因果关系,提示调节肠道菌群或有助于改善肥胖者的IC缺陷。
关键字
延伸阅读本研究的原文信息和链接出处,以及相关解读和评论文章。欢迎读者朋友们推荐!
图片
Gut [IF:19.819]

Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metabolic pathways

肥胖相关的抑制性控制缺陷是通过肠道菌群的一碳和芳香族氨基酸代谢途径的改变而表现在小鼠身上

10.1136/gutjnl-2020-323371

01-29, Article

Abstract & Authors:展开

Abstract:收起
Background: Inhibitory control (IC) is critical to keep long-term goals in everyday life. Bidirectional relationships between IC deficits and obesity are behind unhealthy eating and physical exercise habits.
Methods : We studied gut microbiome composition and functionality, and plasma and faecal metabolomics in association with cognitive tests evaluating inhibitory control (Stroop test) and brain structure in a discovery (n=156), both cross-sectionally and longitudinally, and in an independent replication cohort (n=970). Faecal microbiota transplantation (FMT) in mice evaluated the impact on reversal learning and medial prefrontal cortex (mPFC) transcriptomics.
Results: An interplay among IC, brain structure (in humans) and mPFC transcriptomics (in mice), plasma/faecal metabolomics and the gut metagenome was found. Obesity-dependent alterations in one-carbon metabolism, tryptophan and histidine pathways were associated with IC in the two independent cohorts. Bacterial functions linked to one-carbon metabolism (thyX,dut, exodeoxyribonuclease V), and the anterior cingulate cortex volume were associated with IC, cross-sectionally and longitudinally. FMT from individuals with obesity led to alterations in mice reversal learning. In an independent FMT experiment, human donor’s bacterial functions related to IC deficits were associated with mPFC expression of one-carbon metabolism-related genes of recipient’s mice.
Conclusion: These results highlight the importance of targeting obesity-related impulsive behaviour through the induction of gut microbiota shifts.

First Authors:
Maria Arnoriaga Rodríguez,Jordi Mayneris-Perxachs

Correspondence Authors:
Jordi Mayneris-Perxachs,Rafael Maldonado,José Manuel Fernández-Real

All Authors:
Maria Arnoriaga Rodríguez,Jordi Mayneris-Perxachs,Oren Contreras-Rodríguez,Aurelijus Burokas,Juan-Antonio Ortega-Sanchez,Gerard Blasco,Claudia Coll,Carles Biarnés,Anna Castells-Nobau,Josep Puig,Josep Garre-Olmo,Rafel Ramos,Salvador Pedraza,Ramon Brugada,Joan C Vilanova,Joaquín Serena,Jordi Barretina,Jordi Gich,Vicente Pérez-Brocal,Andrés Moya,Xavier Fernández-Real,Lluis Ramio-Torrentà,Reinald Pamplona,Joaquim Sol,Mariona Jové,Wifredo Ricart,Manuel Portero-Otin,Rafael Maldonado,José Manuel Fernández-Real

评论