Cell:母亲的便便可“修正”剖腹产婴儿的肠道菌群
  • 纳入7名剖腹产(CS)孕妇,收集分娩前3周的粪便样本,在出生后首次哺乳时,为其婴儿进行3.5mg的母亲粪菌移植(FMT),随访3个月;
  • FMT没有对婴儿健康造成不良影响;
  • FMT后,特定细菌在婴儿中出现选择性的富集生长;
  • FMT-CS婴儿的菌群组成和发育情况与CS婴儿不同,而与阴道分娩婴儿相似,CS婴儿中的菌群多样性降低以及拟杆菌和双歧杆菌不足的问题,能被FMT有效修复;
  • 涂抹母亲阴道拭子的婴儿,其肠道菌群与阴道分娩婴儿并不相似。
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mildbreeze
剖腹产婴儿的肠道菌群的组成和发育轨迹,与自然分娩的婴儿非常不同,这可能为孩子的长期健康带来隐患。Cell最新发表的一项来自芬兰的概念验证研究表明,通过口服方法,将母亲分娩前的粪菌移植给剖腹产婴儿,能“修复”婴儿肠道菌群在组成和发育轨迹方面的缺陷,使其与阴道分娩的婴儿变得相似。这种干预措施或许能用于改善剖腹产婴儿的肠道菌群健康,但相关发现仍需开展更大规模的临床试验进行验证,是否有助于婴儿的长期健康也需要进一步观察研究。
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Cell [IF:38.637]

Maternal Fecal Microbiota Transplantation in Cesarean-Born Infants Rapidly Restores Normal Gut Microbial Development: A Proof-of-Concept Study

为剖腹产婴儿进行母体粪菌移植能快速恢复正常的肠道微生物发育:一项概念验证研究

10.1016/j.cell.2020.08.047

2020-10-01, Article

Abstract & Authors:展开

Abstract:收起
Infants born by vaginal delivery are colonized with maternal fecal microbes. Cesarean section (CS) birth disturbs mother-to-neonate transmission. In this study (NCT03568734), we evaluated whether disturbed intestinal microbiota development could be restored in term CS-born infants by postnatal, orally delivered fecal microbiota transplantation (FMT). We recruited 17 mothers, of whom seven were selected after careful screening. Their infants received a diluted fecal sample from their own mothers, taken 3 weeks prior to delivery. All seven infants had an uneventful clinical course during the 3-month follow-up and showed no adverse effects. The temporal development of the fecal microbiota composition of FMT-treated CS-born infants no longer resembled that of untreated CS-born infants but showed significant similarity to that of vaginally born infants. This proof-of-concept study demonstrates that the intestinal microbiota of CS-born infants can be restored postnatally by maternal FMT. However, this should only be done after careful clinical and microbiological screening.

First Authors:
Katri Korpela,Otto Helve

Correspondence Authors:
Willem M De Vos

All Authors:
Katri Korpela,Otto Helve,Kaija-Leena Kolho,Terhi Saisto,Kirsi Skogberg,Evgenia Dikareva,Vedran Stefanovic,Anne Salonen,Sture Andersson,Willem M De Vos

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腾讯网新闻网站

给新生儿喂混有妈妈粪便的母乳,这群科学家证明了一个想法……

药明康德内容团队,2020-10-02

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热心肠智库专家观点精选
张发明 1
治与不治,都是个问题
2020-10-02 11:06