创作:大月半 审核:mildbreeze 03月01日
  • 肠道菌群和中枢神经系统之间的双向交流(菌群-肠-脑轴),参与脑功能调节、神经发育和衰老;
  • 菌群可通过产生神经活性代谢物(如神经递质)、短链脂肪酸等菌群产物、神经(肠神经、迷走神经等)、HPA轴、内分泌(肠激素)、免疫(免疫细胞和细胞因子)等途径,与大脑沟通;
  • 菌群-肠-脑轴紊乱可能是多发性硬化、自闭症、帕金森、阿尔茨海默病、中风和脑损伤、癫痫、肌萎缩性脊髓侧索硬化症和亨廷顿舞蹈症等神经系统疾病的易感因素。
The Lancet Neurology近期发表的重要综述,探讨了菌群-肠-脑轴在神经调控、发育和衰老以及多种神经系统疾病中的作用和机制,并指出未来需要开展更多的纵向研究和随机对照试验,来探索菌群靶向性疗法用于相关疾病治疗的效果。

The gut microbiome in neurological disorders



2019-11-18, Review

Abstract & Authors:展开

Research into the role of the gut microbiome in modulating brain function has rapidly increased over the past 10 years, albeit chiefly in animal models. Increasing clinical and preclinical evidence implicates the microbiome as a possible key susceptibility factor for neurological disorders, including Alzheimer's disease, autism spectrum disorder, multiple sclerosis, Parkinson's disease, and stroke. Cross-sectional clinical studies are bolstering the concept of altered microbial composition contributing to the pathophysiology of such diseases. However, the field is nascent, and interpretation of such data is often difficult given that the composition of the microbiome is influenced by various factors such as diet and exercise. Longitudinal studies and randomised controlled trials in humans are needed to find out if targeting the microbiome can yield novel therapeutic strategies. Systems biology approaches will also be important in integrating such data with genomic and metabolomic datasets from clinical cohorts with neurological disease to help guide individual treatment selection.

First Authors:
John F Cryan

Correspondence Authors:
John F Cryan

All Authors:
John F Cryan,Kenneth J O'Riordan,Kiran Sandhu,Veronica Peterson,Timothy G Dinan