酗酒者的精神和行为问题与肠道和菌群紊乱有关
创作:大力 审核:szx 2020年10月21日
  • 队列研究表明酒精依赖(AD)患者的肠漏和肠道菌群失调与社交能力低下有关;
  • 给抗生素和聚乙二醇处理后的小鼠移植AD患者的粪菌,可复制其社交能力及抑郁样行为上的改变,使髓鞘形成、神经传递受损,并诱导炎症;
  • 移植AD患者粪菌可抑制小鼠的脂肪分解,并促进特定细菌属产生乙醇,从而抑制肝脏生酮作用,减少血液中β-羟基丁酸的合成和释放;
  • 在戒断AD患者中,菌群产生的乙醇的增加及低血浆BHB水平与社交障碍、抑郁及髓鞘形成降低相关。
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Cell Reports上发表的一项最新研究,发现酒精依赖患者的社交障碍与其肠道屏障功能损伤及肠道菌群失调相关,而小鼠的粪菌移植实验证实,肠道菌群的紊乱介导了酒精依赖患者的抑郁及社交行为变化。进一步研究发现,患者肠道菌群产生的乙醇增加,抑制了肝脏生酮作用,导致β-羟基丁酸合成及释放的减少。同时,血液β-羟基丁酸水平的降低与AD患者的髓鞘形成受损、社交障碍及抑郁相关。
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Cell Reports [IF:8.109]

Gut Microbiota-Induced Changes in β-Hydroxybutyrate Metabolism Are Linked to Altered Sociability and Depression in Alcohol Use Disorder

酒精使用障碍患者的社交能力改变和抑郁与肠道菌群诱导的β-羟基丁酸代谢变化相关

10.1016/j.celrep.2020.108238

2020-10-13, Article

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Patients with alcohol use disorder (AUD) present with important emotional, cognitive, and social impairments. The gut microbiota has been recently shown to regulate brain functions and behavior but convincing evidence of its role in AUD is lacking. Here, we show that gut dysbiosis is associated with metabolic alterations that affect behavioral (depression, sociability) and neurobiological (myelination, neurotransmission, inflammation) processes involved in alcohol addiction. By transplanting the gut microbiota from AUD patients to mice, we point out that the production of ethanol by specific bacterial genera and the reduction of lipolysis are associated with a lower hepatic synthesis of β-hydroxybutyrate (BHB), which thereby prevents the neuroprotective effect of BHB. We confirm these results in detoxified AUD patients, in which we observe a persisting ethanol production in the feces as well as correlations among low plasma BHB levels and social impairments, depression, or brain white matter alterations.

First Authors:
Sophie Leclercq

Correspondence Authors:
Philippe De Timary,Nathalie M Delzenne

All Authors:
Sophie Leclercq,Tiphaine Le Roy,Sonia Furgiuele,Valentin Coste,Laure B Bindels,Quentin Leyrolle,Audrey Neyrinck,Caroline Quoilin,Camille Amadieu,Géraldine Petit,Laurence Dricot,Vanessa Tagliatti,Patrice D Cani,Kristin Verbeke,Jean-Marie Colet,Peter Stärkel,Philippe De Timary,Nathalie M Delzenne

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