上海交大张晨虹团队:节食时间影响小鼠肠道菌群和代谢表型
  • 不论白天或夜间(活动期)进食,节食都能改善小鼠代谢,但与夜间进食(CRD)相比,白天进食(CRL)的小鼠表现出肌肉减少等代谢表型差异,及菌群结构和组成的差异;
  • 恢复自由取食后,CRL小鼠出现大量进食行为,而CRD小鼠更能保持节食对脂肪积累、糖代谢、肠屏障和炎症指标的改善效果;
  • 进食时间影响肠道菌群,被节食富集的乳杆菌属OTU在CRD小鼠里丰度更高;
  • 恢复自由取食后,CRD小鼠菌群变得接近未节食的小鼠,而CRL小鼠菌群仍有差异。
主编推荐语
mildbreeze
不规律的进食时间在当今社会很普遍,很多人都习惯在夜间吃东西(比如,晚餐时间过晚和吃夜宵)。热量限制(节食)是改善代谢健康的有效方法,但节食期间的进食时间对肠道菌群、代谢和整体健康的影响仍需研究。上海交通大学张晨虹团队在mSystems发表的一项最新研究,分析了不同时间进食的节食小鼠的代谢表型和肠道菌群,表明将进食时间限制在活跃期(对于小鼠是夜间),或许可以产生更为健康的效果,为节食时间的选择提供了新的证据。
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mSystems [IF:6.633]

Timing of Calorie Restriction in Mice Impacts Host Metabolic Phenotype with Correlative Changes in Gut Microbiota

小鼠热量限制的时间影响与肠道菌群变化相关的宿主代谢表型

10.1128/mSystems.00348-19

2019-12-03, Article

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Calorie restriction (CR) is accompanied by self-imposed daily restriction of food intake and an extended fasting period between meals. The impact of restricting feeding to the dark or light phase on the effects of CR remains elusive. Here, light-fed CR mice showed physiological changes, such as muscle loss, concomitant with changes in the gut microbiota structure and composition. After switching to ad libitum access to food, light-fed mice had a period of food-craving behavior and short-lived physiological changes, while dark-fed mice displayed lasting changes in fat accumulation, glucose metabolism, intestinal barrier function, and systemic inflammatory markers. Moreover, the gut microbiota was modulated by when the food was consumed, and the most abundant Lactobacillus operational taxonomic unit (OTU) promoted by CR was enhanced in dark-fed mice. After switching to ad libitum feeding, the gut microbiota of dark-fed mice returned to the state resembling that of mice fed normal chow ad libitum, but that of light-fed mice was still significantly different from the other two groups. Together, these data indicate that for CR, restricting food consumption to the active phase brought better metabolic phenotype associated with potentially beneficial structural shifts in the gut microbiota.

First Authors:
Liying Zhang

Correspondence Authors:
Chenhong Zhang

All Authors:
Liying Zhang,Xinhe Xue,Rui Zhai,Xin Yang,Hui Li,Liping Zhao,Chenhong Zhang

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