利用恒河猴研究与腹泻相关的肠道菌群发育变化
创作:aluba 审核:aluba 2019年09月06日
  • 使用幼年恒河猴作为腹泻模型;
  • 恒河猴在出生后8个月内的肠道菌群成熟模式与人类婴儿类似,其中人工饲养的幼年恒河猴的菌群与发展中国家的婴儿更加相似;
  • 腹泻恒河猴发病前的肠道菌群中即表现出免疫调节性代谢产物合成通路的富集;
  • 腹泻恒河猴出生后1个月时的普氏菌属菌株丰度升高,出生后8个月时的弯曲菌属丰度升高,Helicobacter macacae丰度降低;
  • 在未发生腹泻的恒河猴中,肠道菌群中短链脂肪酸生成通路富集。
主编推荐语
aluba
幼年恒河猴的腹泻易感性较高,是一种很好的研究腹泻的动物模型。Genome Biology上发表的一项最新研究,发现幼年恒河猴与人类婴儿的肠道菌群发育成熟有着相似的模式,并鉴定出了一些与腹泻相关的肠道菌群变化。
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Genome Biology [IF:13.583]

Maturation of the infant rhesus macaque gut microbiome and its role in the development of diarrheal disease

幼年恒河猴的肠道菌群成熟及其在腹泻发展中的作用

10.1186/s13059-019-1789-x

2019-08-26, Article

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BACKGROUND: Diarrhea is the second leading cause of death in children under 5 years of age. Enhanced understanding of causal pathways, pathogenesis, and sequelae of diarrhea is urgently needed. Although the gut microbiota is believed to play a role in susceptibility to diarrheal diseases, our understanding of this association remains incomplete. Infant rhesus macaques (Macaca mulatta) are susceptible to diarrhea making them an ideal model to address this question.
RESULTS: The maturation of the infant rhesus macaque gut microbiome throughout the first 8 months of life occurs in a similar pattern as that described for human infants. Moreover, the microbiome of the captive reared infant rhesus macaque more closely resembles that of human infants in the developing world than in the western world. Importantly, prior to disease onset, the gut microbiome of infants that later develop diarrhea is enriched in pathways of immunomodulatory metabolite synthesis, while those of infants that remain asymptomatic are enriched in pathways for short-chain fatty acid production. We identify Prevotella strains that are more abundant at 1 month in infants that later develop diarrhea. At 8 months, the microbiomes of animals that experience diarrhea show increased abundance of Campylobacter and a reduction in Helicobacter macacae.
CONCLUSION: The composition of the microbial community could provide a phenotypic marker of an infant's susceptibility to diarrheal disease. Given the significant physiological and immunological similarities between human and nonhuman primates, these findings provide potential markers of susceptibility to diarrhea that could be modulated to improve infant health, especially in the developing world.

First Authors:
Nicholas Rhoades

Correspondence Authors:
Ilhem Messaoudi

All Authors:
Nicholas Rhoades,Tasha Barr,Sara Hendrickson,Kamm Prongay,Andrew Haertel,Leanne Gill,Laura Garzel,Katrine Whiteson,Mark Slifka,Ilhem Messaoudi

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