Nature 子刊:胆汁酸驱动新生儿肠道菌群的成熟
创作:Unbroken 审核:nana 2020年07月31日
  • 分析同一窝小鼠在刚出生、婴儿期和断奶至成年期间小肠和大肠的菌群组成,及小鼠肝脏的代谢物组成;
  • 小鼠的菌群组成和代谢变化具有年龄依赖性,如小肠和结肠菌群在生命早期(21天前)难以区分,断奶后呈现明显差异,及小鼠断奶后总胆汁酸库及其组成发生显著变化等;
  • 关联分析表明,胆汁酸是早期肠道菌群成熟的强有力的驱动因素,并确定了与早期肠道菌群成熟相关的特异性胆汁酸;
  • 新生小鼠口服胆汁酸,可加速小鼠菌群的成熟。
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新生儿出生后,肠道暴露于母体细菌和环境细菌中,相继形成密集而高度变化的肠道菌群。虽然外源性因素对新生儿肠道菌群的影响已被广泛研究,但宿主介导的机制仍然很大程度上未被探索。并且,伴随着微生物定植,肝脏也经历了从造血器官到代谢调节和免疫监测的中枢器官的功能转变。《Nature Communications》最近发表的研究,旨在分析肝脏代谢的胆汁酸对早期肠道菌群的影响。结果表明,宿主胆汁酸能影响出生后肠道菌群组成,并促进肠道菌群的成熟。本研究结果或可用于弥补必要医疗干预引起的不利影响 ,如早期使用抗生素治疗,并扶植有益微生物以促肠道稳态。
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Bile acids drive the newborn’s gut microbiota maturation

胆汁酸驱动新生儿肠道菌群的成熟

10.1038/s41467-020-17183-8

2020-07-23, Article

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Following birth, the neonatal intestine is exposed to maternal and environmental bacteria that successively form a dense and highly dynamic intestinal microbiota. Whereas the effect of exogenous factors has been extensively investigated, endogenous, host-mediated mechanisms have remained largely unexplored. Concomitantly with microbial colonization, the liver undergoes functional transition from a hematopoietic organ to a central organ of metabolic regulation and immune surveillance. The aim of the present study was to analyze the influence of the developing hepatic function and liver metabolism on the early intestinal microbiota. Here, we report on the characterization of the colonization dynamics and liver metabolism in the murine gastrointestinal tract (n = 6–10 per age group) using metabolomic and microbial profiling in combination with multivariate analysis. We observed major age-dependent microbial and metabolic changes and identified bile acids as potent drivers of the early intestinal microbiota maturation. Consistently, oral administration of tauro-cholic acid or β-tauro-murocholic acid to newborn mice (n = 7–14 per group) accelerated postnatal microbiota maturation.

First Authors:
N van Best

Correspondence Authors:
J Penders,M W Hornef

All Authors:
N van Best,U Rolle-Kampczyk,F G Schaap,M Basic,S W M Olde Damink,A Bleich,P H M Savelkoul,M von Bergen,J Penders,M W Hornef

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