Cell子刊:隔日禁食改善成年人健康,或能延缓衰老
  • 临床试验表明,隔日禁食(ADF)使整体热量摄入减少28-37%,比持续性热量限制容易坚持,长期(>6个月)安全性良好,不损害免疫和骨骼健康;
  • 4周ADF可减少4.5%体重(尤其躯干脂肪),改善脂肪与瘦体重比值和心血管标志物,增加酮体β羟基丁酸;
  • 长期ADF能改善血脂、降低衰老相关炎症标志物sICAM-1和代谢调节因子T3(其低水平与长寿相关)的水平;
  • 并引起血液代谢组周期性变化,促衰老氨基酸甲硫氨酸被周期性清除,多不饱和脂肪酸升高。
主编推荐语
mildbreeze
隔日禁食(ADF)是一种间歇性禁食方法,以两天为一个周期,包括12小时的放开吃和36小时的严格禁食。Cell Metabolism最新发表的一项临床试验,纳入了90名健康中年受试者(不胖、无糖尿病),研究了长期(>6个月)和短期(4周)ADF的作用。该研究表明,ADF在改善心血管指标和减肥方面,具有与持续性热量限制(CR)类似的效果,但比CR更容易坚持。长期ADF还降低了衰老相关标志物水平,且安全性良好。不过研究者也提出,普通人若要进行ADF应先咨询医生,并确保饮食平衡健康。
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Cell Metabolism [IF:21.567]

Alternate Day Fasting Improves Physiological and Molecular Markers of Aging in Healthy, Non-obese Humans

隔日禁食在健康非肥胖人类中改善了衰老的生理和分子标志物

10.1016/j.cmet.2019.07.016

2019-08-27, Article

Abstract & Authors:展开

Abstract:收起
Caloric restriction and intermittent fasting are known to prolong life- and healthspan in model organisms, while their effects on humans are less well studied. In a randomized controlled trial study (ClinicalTrials.gov identifier: NCT02673515), we show that 4 weeks of strict alternate day fasting (ADF) improved markers of general health in healthy, middle-aged humans while causing a 37% calorie reduction on average. No adverse effects occurred even after >6 months. ADF improved cardiovascular markers, reduced fat mass (particularly the trunk fat), improving the fat-to-lean ratio, and increased β-hydroxybutyrate, even on non-fasting days. On fasting days, the pro-aging amino-acid methionine, among others, was periodically depleted, while polyunsaturated fatty acids were elevated. We found reduced levels sICAM-1 (an age-associated inflammatory marker), low-density lipoprotein, and the metabolic regulator triiodothyronine after long-term ADF. These results shed light on the physiological impact of ADF and supports its safety. ADF could eventually become a clinically relevant intervention.

First Authors:
Slaven Stekovic,Sebastian J Hofer,Norbert Tripolt

Correspondence Authors:
Frank Madeo

All Authors:
Slaven Stekovic,Sebastian J Hofer,Norbert Tripolt,Miguel A Aon,Philipp Royer,Lukas Pein,Julia T Stadler,Tobias Pendl,Barbara Prietl,Jasmin Url,Sabrina Schroeder,Jelena Tadic,Tobias Eisenberg,Christoph Magnes,Michael Stumpe,Elmar Zuegner,Natalie Bordag,Regina Riedl,Albrecht Schmidt,Ewald Kolesnik,Nicolas Verheyen,Anna Springer,Tobias Madl,Frank Sinner,Rafael de Cabo,Guido Kroemer,Barbara Obermayer-Pietsch,Jöm Dengjel,Harald Sourij,Thomas R Pieber,Frank Madeo

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Cell Metabolism期刊

Alternate-Day Fasting Gets a Safe Bill of Health

Leonie K. Heilbronn, Satchidananda Panda,2019-09-03

点评:Cell Metabolism同期配发的评论解读文章。

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生物探索微信公众号

Cell又发减肥文,隔日禁食,月瘦6斤不费劲

2019-09-02

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生物谷微信公众号

“辟谷”原来真的能延年益寿?

2019-09-19

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Nature Reviews Endocrinology期刊

Safety and efficacy of alternate day fasting

2019-09-26

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