肠道菌群或可用于预测克罗恩病患者的小肠粘膜愈合
  • 纳入38名克罗恩病患者,根据胶囊或球囊辅助内窥镜检查的整个小肠的溃疡状况,将病人分为溃疡组(24名)和粘膜愈合组(14名);
  • 溃疡组具有较低的菌群α多样性,柔嫩梭菌属、毛螺菌科、普雷沃菌属、小杆菌属、链球菌、梭菌等6种类群在粘膜愈合组富集;
  • 使用粘膜愈合组富集的6种类群对粘膜愈合进行预测评分,发现其预测粘膜愈合的敏感性和特异性分别为0.643和0.917;
  • 这种基于肠道菌群特征的预测评分或可作为小肠粘膜愈合的生物标志物。
主编推荐语
爱的抉择
粘膜愈合是治疗克罗恩病的主要目标,但有些病人无法进行整个小肠的内窥镜评估。克罗恩病与肠道菌群密切相关,但肠道菌群和小肠中克罗恩病活动性之间的关系仍不清楚。Journal of Gastroenterology近期发表的文章,发现粪便菌群与克罗恩病人整个小肠的病情活性性相关,提取粘膜愈合组的富集性菌群特征进行预测评分,该评分可以很好地预测粘膜愈合的程度,或可用作预测粘膜愈合的生物标志物。
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The microbiome can predict mucosal healing in small intestine in patients with Crohn's disease

克罗恩病患者的肠道菌群可预测小肠的粘膜愈合

10.1007/s00535-020-01728-1

2020-10-16, Article

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BACKGROUND: Mucosal healing is the main treatment goal for Crohn's disease. In this situation, some patients have difficulty with endoscopic evaluation of the entire small intestine. Crohn's disease is closely associated with the gut microbiota, but the relationship between the microbiome and disease activity in the small intestine remains unclear. We examined the association between the microbiome and endoscopic findings in the small intestine and determined whether the microbiome can predict mucosal healing.
METHODS: The patients with Crohn's disease who were scheduled for capsule or balloon-assisted endoscopy were included in this prospective study. Patients whose entire small intestine was evaluated were divided into two groups based on ulcerative findings. The microbiomes in the fecal samples were analyzed using 16S rRNA sequencing.
RESULTS: The 38 enrolled patients were divided into the ulcer group (24) and mucosal healing group (14). The ulcer group exhibited lower α diversity. Six genera, namely Faecalibacterium (P = 0.008), Lachnospira (P = 0.009), Paraprevotella (P = 0.01), Dialister (P = 0.012), Streptococcus (P = 0.025), and Clostridium (P = 0.028) were enriched in the mucosal healing group. A predictive score for mucosal healing was defined using these six genera. The area under the curve was 0.795 and the sensitivity and specificity for predicting mucosal healing were 0.643 and 0.917, respectively.
CONCLUSIONS: Fecal microbiome is corelated with disease activity in the entire small intestine in Crohn's disease patients. The predictive score proposed by microbiota characteristics was a potential biomarker for mucosal healing in the small intestine.

First Authors:
Shun Hattori

Correspondence Authors:
Masanao Nakamura

All Authors:
Shun Hattori,Masanao Nakamura,Takeshi Yamamura,Keiko Maeda,Tsunaki Sawada,Yasuyuki Mizutani,Kenta Yamamoto,Takuya Ishikawa,Kazuhiro Furukawa,Eizaburo Ohno,Takashi Honda,Hiroki Kawashima,Masatoshi Ishigami,Yoshiki Hirooka,Mitsuhiro Fujishiro

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