一图读懂:人体菌群研究的阶段性总结(Nature医学必读综述)
  • 人体菌群已证实与多种疾病相关,菌群研究正从描述和关联性研究,向机制和应用性研究转变;
  • 每个人高度个性化的菌群受许多因素共同影响:发育早期的遗传和免疫互作、所处身体部位、饮食、抗生素、生活方式;
  • 人体菌群不断发生着动态变化,弹性和稳定性在不同时间尺度上并存,菌群的变化率存在个体差异;
  • 研究菌群在疾病中的作用机制应注意:深入菌株层面,在人群研究中鉴定疾病相关菌群特征并用动物实验验证,菌群本身可作为疾病标志物。
#一张图读懂系列文献#
主编推荐语
mildbreeze
Nature Medicine刚刚上线的由Rob Knight主笔的综述,回顾了现阶段人体菌群领域的进展情况,重点总结了人体研究的相关结论,也包括人体与动物研究相结合以阐述因果性的例子。干货很多,此处仅做概述性导读,文章具体内容值得专业人士深挖。
关键字
延伸阅读本研究的原文信息和链接出处,以及相关解读和评论文章。欢迎读者朋友们推荐!
图片
Nature Medicine [IF:87.241]

Current understanding of the human microbiome

目前对人体微生物组的认知

10.1038/nm.4517

2018-04-10, Review

Abstract & Authors:展开

Abstract:收起
Our understanding of the link between the human microbiome and disease, including obesity, inflammatory bowel disease, arthritis and autism, is rapidly expanding. Improvements in the throughput and accuracy of DNA sequencing of the genomes of microbial communities that are associated with human samples, complemented by analysis of transcriptomes, proteomes, metabolomes and immunomes and by mechanistic experiments in model systems, have vastly improved our ability to understand the structure and function of the microbiome in both diseased and healthy states. However, many challenges remain. In this review, we focus on studies in humans to describe these challenges and propose strategies that leverage existing knowledge to move rapidly from correlation to causation and ultimately to translation into therapies.

First Authors:
Jack A Gilbert

Correspondence Authors:
Rob Knight

All Authors:
Jack A Gilbert,Martin J Blaser,J Gregory Caporaso,Janet K Jansson,Susan V Lynch,Rob Knight

评论