湖南农大:肥胖中的生物钟与脂质代谢互作(综述)
  • 昼夜节律主要由CLOCK/BMAL1异质二聚体vsPER-CRY节律蛋白之间形成的转录-翻译反馈回路控制;
  • 生物钟基因的缺失或过表达均与肥胖相关,而环境因素打乱昼夜节律如时差可导致脂代谢紊乱增加肥胖风险;
  • 激素如褪黑素、瘦素、糖皮质激素,肠道菌群包括其自身节律、代谢产物、厚壁菌门/拟杆菌比率以及机体能量调节,影响昼夜节律与脂质代谢在生理与肥胖中的互作;
  • 进食时间和膳食营养成分是影响昼夜节律和脂质代谢相互作用的两个关键授时因子。
主编推荐语
solo
昼夜节律是一种由生物钟驱动、内源性、持续的以24小时为周期的生理活动。2017年三位遗传学家因对昼夜节律分子机制的研究包括发现PER(period)基因,分享诺贝尔生理医学奖。由此人们对生活规律、生物钟调控与肥胖之间关系的认知越来越全面和深入。湖南农业大学尹杰团队发表综述,讨论遗传、环境因素造成的昼夜节律紊乱对代谢健康的影响,以及多种分子调节机制和授时因子的作用。作者提出“昼夜节律卫生”概念,倡导人们保持健康的生活习惯从而减少肥胖。
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Circadian Rhythms and Obesity: Timekeeping Governs Lipid Metabolism

昼夜节律与肥胖:计时管理下的脂质代谢

10.1111/jpi.12682

2020-07-13, Review

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Almost all living organisms have evolved autoregulatory transcriptional‐translational feedback loops that produce oscillations with a period of approximately 24‐h. These endogenous time keeping mechanisms are called circadian clocks. The main function of these circadian clocks is to drive overt circadian rhythms in the physiology of the organisms to ensure that main physiological functions are in synchrony with the external environment. Disruption of circadian rhythms caused by genetic or environmental factors has long‐term consequences for metabolic health. Of relevance, host circadian rhythmicity and lipid metabolism are increasingly recognized to cross‐regulate and the circadian clock‐lipid metabolism interplay may involve in the development of obesity. Multiple systemic and molecular mechanisms, such as hormones (i.e., melatonin, leptin, and glucocorticoid), the gut microbiome, and energy metabolism, link the circadian clock and lipid metabolism, and predictably, the deregulation of circadian clock‐lipid metabolism interplay can increase the risk of obesity, which in turn may exacerbate circadian disorganization. Feeding time and dietary nutrients are two of key environmental Zeitgebers affecting the circadian rhythm‐lipid metabolism interplay and the influencing mechanisms in obesity development are highlighted in this review. Together, the characterization of the clock machinery in lipid metabolism aimed at producing a healthy circadian lifestyle may improve obesity care.

First Authors:
Yuying Li

Correspondence Authors:
Jie Yin

All Authors:
Yuying Li,Jie Ma,Kang Yao,Wenxuan Su,Bie Tan,Xin Wu,Xingguo Huang,Tiejun Li,Yulong Yin,Gianluca Tosini,Jie Yin

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