Science:1500万年来,菌群与人类共进化的“铁证”?
  • 研究肠道里占主导地位的细菌类群的多重进化谱系,及它们与人类、黑猩猩、倭黑猩猩、大猩猩的协同物种形成;
  • 分析人科动物肠道微生物组的菌株水平细菌多样性,表明在成千上万世代里,拟杆菌科和双歧杆菌科的进化支与宿主谱系保持一致;
  • 协同种化的肠道细菌的分化年代与人科动物一致,在人科动物进化过程中,细胞核、线粒体和肠道细菌的基因组是同步分化的;
  • 人类肠道细菌起源于古老的同时在人类和非洲猿中形成的共生物种。
主编推荐语
热心肠先生
今天出版的Science,放出了这个重量级的进化相关研究论文,强烈支持了人是人和微生物的超级生物体,这对于理解人-菌群共生、免疫系统塑造、人类发育进程无疑具有重大意义。推荐大家看一看,被科普一下。
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Science [IF:63.714]

Cospeciation of gut microbiota with hominids

肠道菌群与人科动物的协同种化

10.1126/science.aaf3951

2016-07-22, Article

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The evolutionary origins of the bacterial lineages that populate the human gut are unknown. Here we show that multiple lineages of the predominant bacterial taxa in the gut arose via cospeciation with humans, chimpanzees, bonobos, and gorillas over the past 15 million years. Analyses of strain-level bacterial diversity within hominid gut microbiomes revealed that clades of Bacteroidaceae and Bifidobacteriaceae have been maintained exclusively within host lineages across hundreds of thousands of host generations. Divergence times of these cospeciating gut bacteria are congruent with those of hominids, indicating that nuclear, mitochondrial, and gut bacterial genomes diversified in concert during hominid evolution. This study identifies human gut bacteria descended from ancient symbionts that speciated simultaneously with humans and the African apes.

First Authors:
Andrew H Moeller

Correspondence Authors:
Howard Ochman

All Authors:
Andrew H Moeller,Alejandro Caro-Quintero,Deus Mjungu,Alexander V Georgiev,Elizabeth V Lonsdorf,Martin N Muller,Anne E Pusey,Martine Peeters,Beatrice H Hahn,Howard Ochman

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