• 三氯卡班是一种常用的非处方抗生素,可通过母乳传播给后代;
  • 妊娠期及哺乳期接触三氯卡班可显著降低后代的肠道菌群的系统发育多样性;
  • 怀孕的大鼠在孕期的第18天出现三氯卡班诱导的肠道菌群失调;
  • 在新生大鼠中,出生后第12天开始,三氯卡班诱导的肠道菌群失调开始出现,并在出生后第16天达到显著差异水平
蓝灿辉 | 热心肠先生
Scientific Reports [IF:4.379]

Temporal Development of Gut Microbiota in Triclocarban Exposed Pregnant and Neonatal Rats



2016-09-20, Article

Abstract & Authors:展开

BACKGROUND: Alteration of gut microbial colonization process may influence susceptibility of the newborn/infant to infectious and chronic disease. Infectious disease risk leads to widespread use of non-prescription antimicrobials in household products such as Triclocarban (TCC), an antimicrobial compound in personal care products. TCC concentrates in and is transferred through the milk to suckling offspring.
RESULTS: TCC exposure during gestation and lactation significantly reduced phylogenetic diversity (PD) among exposed dams and neonates. Among dams using weighted UniFrac distances, TCC induced significant dysbiosis of gut microbiota by gestational day (GD) 18, a trend that continued after delivery. Similarly, an overall restructuring of gut microbiota occurred in neonates. By postnatal day (PND) 12, communities separated based on exposure status and became significantly different at PND 16.
CONCLUSION: The ability of TCC to drive microbial dysbiosis warrants future investigation to evaluate the safety of non-prescription antimicrobial use, including TCC, during critical exposure windows.

First Authors:
Rebekah C Kennedy

Correspondence Authors:
Jiangang Chen

All Authors:
Rebekah C Kennedy,Russell R Fling,Michael S Robeson,Arnold M Saxton,Robert L Donnell,John L Darcy,David A Bemis,Jiang Liu,Ling Zhao,Jiangang Chen