Cell子刊:IgA与有益菌的结合受到营养摄入的调控
创作:szx 审核:szx 2020年04月15日
  • 在营养不良小鼠模型中,可靶向结合乳杆菌属的IgA显著减少,乳杆菌属与IgA的结合能力降低;
  • IgA结合诱导乳杆菌属的聚集,但对其粘膜粘附影响较小;
  • IgA-乳杆菌属之间的结合互作由聚糖介导,在营养不良条件下,乳杆菌属的表面结构发生变化以适应环境的改变,导致与IgA结合及粘膜粘附能力的降低;
  • 营养摄入可增强乳杆菌属的IgA结合能力,且不依赖于宿主IgA;
  • 乳杆菌属的IgA结合能力与其碳水化合物转运及代谢相关基因中的突变相关。
主编推荐语
szx
IgA在肠道中调控宿主-菌群互作稳态,在营养不良儿童中,IgA对有益细菌的识别降低,但背后的机制尚未明确。Cell Host and Microbe上发表的一项最新研究,发现聚糖介导了IgA与菌群的结合互作,而在营养不良的条件下,乳杆菌属等有益菌可能通过改变其表面的聚糖结构以适应环境的变化,导致与IgA结合的能力降低,并降低了这些菌在肠粘膜的定殖能力。
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Commensal Bacteria Modulate Immunoglobulin A Binding in Response to Host Nutrition

共生细菌调节IgA结合以应答宿主营养

10.1016/j.chom.2020.03.012

2020-04-13, Article

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Immunoglobulin (Ig) A controls host-microbial homeostasis in the gut. IgA recognition of beneficial bacteria is decreased in acutely undernourished children, but the factors driving these changes in IgA targeting are unknown. Child undernutrition is a global health challenge that is exacerbated by poor sanitation and intestinal inflammation. To understand how nutrition impacts immune-microbe interactions, we used a mouse model of undernutrition with or without fecal-oral exposure and assessed IgA-bacterial targeting from weaning to adulthood. In contrast to healthy control mice, undernourished mice fail to develop IgA recognition of intestinal Lactobacillus. Glycan-mediated interactions between Lactobacillus and host antibodies are lost in undernourished mice due to rapid bacterial adaptation. Lactobacillus adaptations occur in direct response to nutritional pressure, independently of host IgA, and are associated with reduced mucosal colonization and with bacterial mutations in carbohydrate processing genes. Together these data indicate that diet-driven bacterial adaptations shape IgA recognition in the gut.

First Authors:
Kelsey E Huus

Correspondence Authors:
B Brett Finlay

All Authors:
Kelsey E Huus,Kylynda C Bauer,Eric M Brown,Tahereh Bozorgmehr,Sarah E Woodward,Antonio Serapio-Palacios,Rozlyn CT Boutin,Charisse Petersen,B Brett Finlay

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Cell Host and Microbe期刊

Nourishing the Microbiota to Promote Mucosal Immunity

2020-06-10

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