姜黄素用于大肠癌防治的现状(综述)
创作:orchid 审核:Lexi 2020年03月16日
  • 姜黄素可有效抑制结直肠癌(CRC)各发展阶段,其对CRC的治疗作用已在临床前和临床研究中得到验证;
  • 姜黄素可调节肠道微生物环境、保护肠道屏障功能、促进胃肠道抗炎活性、调节癌细胞自噬、靶向癌症干细胞、可做化学增敏剂、调节癌细胞表观遗传和细胞周期等;
  • 多个临床试验中,姜黄素被用于预防CRC和化疗辅助,并作为潜在的天然助推器,用于开发癌症免疫治疗;
  • 姜黄素在癌症防治中的局限在于其吸收度低、代谢快,导致生物利用度低。
主编推荐语
Lexi
姜黄素提取于姜黄属植物,在印度阿育吠陀和传统中医中被用于治疗包括癌症在内的多种慢性疾病。过去几十年里有大量研究表明,姜黄素作用于癌症相关关键信号通路,表现出强大的抗癌活性。最新发表在Seminars in Cancer Biology的综述介绍了姜黄素在抗结直肠癌(CRC)领域的最新进展和展望,包括其影响的基本细胞机制、临床证据的现状、以及癌症防治中的局限等。
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Curcumin and Colorectal Cancer: An Update and Current Perspective On This Natural Medicine

姜黄素与结直肠癌:该天然药物的最新研究进展

10.1016/j.semcancer.2020.02.011

2020-02-20, Article

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Colorectal cancer (CRC) is one of most common malignancies worldwide and its incidence is still growing. In spite of recent advances in targeted therapies, their clinical efficacy has been limited, non-curative and unaffordable. A growing body of literature indicates that CRC is a multi-modal disease, where a variety of factors within the tumor microenvironment play a significant role in its pathogenesis. For instance, imbalance in gut microbial profiles and impaired intestinal barrier function contribute to the overall intestinal inflammation and initiation of CRC. Moreover, persistent chronic inflammation favors a tumor microenvironment for the growth of cancer. In addition, autophagy or ‘self-eating’ is a surveillance mechanism involved in the degradation of cellular constituents that are generated under stressful conditions. Cancer stem cells (CSCs), on the other hand, engage in the onset of CRC and are able to endow cancer cells with chemo-resistance. Furthermore, the aberrant epigenetic alterations promote CRC. These evidences highlight the need for multi-targeted approaches that are not only safe and inexpensive but offer a more effective alternative to current generation of targeted drugs. Curcumin, derived from the plant Curcuma longa, represents one such option that has a long history of its use for a variety of chronic disease including cancer, in Indian ayurvedic and traditional Chinese medicine. Scientific evidence over the past few decades have overwhelmingly shown that curcumin exhibits a multitude of anti-cancer activities orchestrated through key signaling pathways associated with cancer. In this article, we will present a current update and perspective on this natural medicine – incorporating the basic cellular mechanisms it effects and the current state of clinical evidence, challenges and promise for its use as a cancer preventative and potential adjunct together with modern therapies for CRC patients.

First Authors:
Wenhao Weng

Correspondence Authors:
Ajay Goel

All Authors:
Wenhao Weng,Ajay Goel

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