Lancet子刊:改善大脑的胰岛素作用,防治代谢和认知疾病(综述)
创作:楸楸 审核:mildbreeze 2020年12月18日
  • 胰岛素可作用于中枢神经系统来调节行为和系统代谢;
  • 增强中枢胰岛素作用可调节外周代谢、增强全身胰岛素敏感性并抑制内源性葡萄糖生成;
  • 中枢胰岛素通过降低美味食物诱惑和增强认知控制来减少食物摄入;
  • 动物模型中,胰岛素可调节由多巴胺系统驱动的中脑边缘奖励神经回路,而肥胖者中此机制受损,从而可能增加2型糖尿病和相关疾病的风险;
  • 改善大脑的胰岛素抵抗,或是防治代谢和认知疾病的新思路。
主编推荐语
mildbreeze
胰岛素信号不仅影响机体代谢,也对大脑健康至关重要,糖尿病患者发生认知障碍和痴呆的风险增加。The Lancet Diabetes and Endocrinology近期发表的综述,介绍了胰岛素在大脑中的作用机制,及其对认知功能和外周代谢的影响,表明改善大脑中的胰岛素抵抗,可能是治疗和预防多种慢性疾病的新思路。
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Central nervous pathways of insulin action in the control of metabolism and food intake

控制新陈代谢和食物摄入中的胰岛素作用的中枢神经通路(综述)

10.1016/S2213-8587(20)30113-3

2020-06-01, Article

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Insulin acts on the CNS to modulate behaviour and systemic metabolism. Disturbances in brain insulin action represent a possible link between metabolic and cognitive health. Current findings from human research suggest that boosting central insulin action in the brain modulates peripheral metabolism, enhancing whole-body insulin sensitivity and suppressing endogenous glucose production. Moreover, central insulin action curbs food intake by reducing the salience of highly palatable food cues and increasing cognitive control. Animal models show that the mesocorticolimbic circuitry is finely tuned in response to insulin, driven mainly by the dopamine system. These mechanisms are impaired in people with obesity, which might increase their risk of developing type 2 diabetes and associated diseases. Overall, current findings highlight the role of insulin action in the brain and its consequences on peripheral metabolism and cognition. Hence, improving central insulin action could represent a therapeutic option for people at an increased risk of developing metabolic and cognitive diseases.

First Authors:
Stephanie Kullmann

Correspondence Authors:
Stephanie Kullmann

All Authors:
Stephanie Kullmann,Andre Kleinridders,Dana M Small,Andreas Fritsche,Hans-Ulrich Häring,Hubert Preissl,Martin Heni

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