陕西师范大学:石榴皮提取物调节肠道菌群,或能缓解多发性硬化
创作:szx 审核:szx 01月12日
  • 石榴皮提取物(PPE)中的主要成分包括多酚、类黄酮、氨基酸、碳水化合物、脂肪酸、脂质、核苷酸、有机酸、酒精、维生素;
  • 口服PPE(100mg/kg/天)可有效缓解EAE小鼠模型的症状,并抑制中枢神经系统的炎症因子浸润及髓鞘损失;
  • 口服PPE可重塑EAE小鼠的肠道菌群,显著富集乳杆菌科,并显著减少产碱菌科及Acidaminococcacea;
  • 将PPE处理后的小鼠的粪菌移植给EAE小鼠,可显著延缓疾病的进展。
主编推荐语
szx
越来越多的证据表明,肠道菌群失调可能是多发性硬化(MS)及对应的动物模型——实验性自身免疫性脑脊髓炎(EAE)的风险因素之一。陕西师范大学的张媛团队在Gut Microbes上发表的一项最新研究,发现口服石榴皮提取物可通过调节肠道菌群,从而显著缓解EAE小鼠的疾病严重程度。
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Gut Microbes [IF:7.74]

Pomegranate peel extract ameliorates the severity of experimental autoimmune encephalomyelitis via modulation of gut microbiota

石榴皮提取物通过调节肠道菌群缓解实验性自身免疫性脑脊髓炎的严重程度

10.1080/19490976.2020.1857515

2020-12-17, Article

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Multiple sclerosis (MS) is a CNS autoimmune disease characterized by demyelination and inflammatory infiltration with a high disability rate. Increasing evidence has demonstrated the importance of gut microbiota as an environmental risk factor in MS and its animal model experimental autoimmune encephalomyelitis (EAE). Diet is the main determinant of gut microbiota composition and function, which greatly affects the shaping of microbial structure. Pomegranate peel, a waste product in the production of juice, is rich in health-promoting compounds. However, its individual constituents, immunoregulatory activities, and action associated with bacterial diversity in the gut microbiota are largely unknown. Here, the main nutrient ingredients of pomegranate peel extract (PPE) were identified as phenols, flavonoids, amino acids, carbohydrates, fatty acids, lipids, nucleotides, organic acids, alcohols, and vitamins via metabolomics evaluation. We found, for the first time, oral PPE (100 mg/kg/day) not only effectively relieves EAE, inhibits CNS inflammatory factor infiltration and myelin loss, but also reshapes gut microbiota. Furthermore, recipient EAE mice with fecal transplantation from the PPE-treated donor delayed the disease development significantly. 16S rRNA gene sequencing revealed the increased gut microbiota richness in PPE-treated group. Among them, Lactobacillaceae enriched significantly, while Alcaligenaceae and Acidaminococcacea decreased remarkably. In conclusion, our data demonstrated that gut microbiota mediated the beneficial effects of oral PPE on EAE, and provided new ideas for developing the prebiotic value of pomegranate peel for the treatment of autoimmune diseases.

First Authors:
Xin-Yu Lu,Bing Han

Correspondence Authors:
Yuan Zhang

All Authors:
Xin-Yu Lu,Bing Han,Xin Deng,Si-Ying Deng,Yan-Yan Zhang,Pei-Xin Shen,Teng Hui,Rui-Heng Chen,Xing Li,Yuan Zhang

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