近20万人数据:多喝含糖饮料或人工甜味剂饮料,或增加2型糖尿病风险
创作:szx 审核:szx 2019年11月01日
  • 纳入3项美国队列研究中的192352名受试者,进行2783210人-年的随访,期间共发生11906例2型糖尿病;
  • 随访期间每4年记录一次饮料摄入的变化;
  • 在校正BMI、饮食、生活方式后,每天摄入的含糖饮料及100%果汁增加0.5份,与随后4年内2型糖尿病风险上升16%相关;
  • 每天摄入的人工甜味剂饮料增加0.5份,与随后4年内2型糖尿比风险上升18%相关;
  • 将每天摄入的1份含糖饮料用水、咖啡或茶(而非人工甜味剂饮料)替代,与2型糖尿病风险降低2-10%相关。
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szx
Diabetes Care上发表的一项前瞻性队列研究结果,对近20万人进行了超过10年的随访后发现,摄入更多的含糖饮料(包括纯果汁)或人工甜味剂饮料,与之后的2型糖尿病风险增加显著相关。
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Diabetes Care [IF:16.019]

Changes in Consumption of Sugary Beverages and Artificially Sweetened Beverages and Subsequent Risk of Type 2 Diabetes: Results From Three Large Prospective U.S. Cohorts of Women and Men

含糖饮料及人工甜味剂饮料的摄入变化与随后的2型糖尿病风险:来自3项美国大型前瞻性队列研究的结果

10.2337/dc19-0734

2019-10-03, Article

Abstract & Authors:展开

Abstract:收起
OBJECTIVE: We evaluated the associations of long-term changes in consumption of sugary beverages (including sugar-sweetened beverages and 100% fruit juices) and artificially sweetened beverages (ASBs) with subsequent risk of type 2 diabetes.
RESEARCH DESIGN AND METHODS: We followed up 76,531 women in the Nurses’ Health Study (1986–2012), 81,597 women in the Nurses’ Health Study II (1991–2013), and 34,224 men in the Health Professionals’ Follow-up Study (1986–2012). Changes in beverage consumption (in 8-ounce serving/day) were calculated from food frequency questionnaires administered every 4 years. Multivariable Cox proportional regression models were used to calculate hazard ratios for diabetes associated with changes in beverage consumption. Results of the three cohorts were pooled using an inverse variance–weighted, fixed-effect meta-analysis.
RESULTS: During 2,783,210 person-years of follow-up, we documented 11,906 incident cases of type 2 diabetes. After adjustment for BMI and initial and changes in diet and lifestyle covariates, increasing total sugary beverage intake (including both sugar-sweetened beverages and 100% fruit juices) by >0.50 serving/day over a 4-year period was associated with a 16% (95% CI 1%, 34%) higher diabetes risk in the subsequent 4 years. Increasing ASB consumption by >0.50 serving/day was associated with 18% (2–36%) higher diabetes risk. Replacing one daily serving of sugary beverage with water, coffee or tea, but not ASB, was associated with a 2–10% lower diabetes risk.
CONCLUSIONS: Increasing consumption of sugary beverages or ASBs was associated with a higher risk of type 2 diabetes, albeit the latter may be affected by reverse causation and surveillance bias.

First Authors:
Jean-Philippe Drouin-Chartier,Yan Zheng

Correspondence Authors:
Jean-Philippe Drouin-Chartier,Frank B Hu

All Authors:
Jean-Philippe Drouin-Chartier,Yan Zheng,Yanping Li,Vasanti Malik,An Pan,Shilpa N Bhupathiraju,Deirdre K Tobias,JoAnn E Manson,Walter C Willett,Frank B Hu

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Harvard T.H. Chan School of Public Health

Drinking more sugary beverages of any type may increase type 2 diabetes risk

2019-10-03

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