• 共纳入8项观察性研究(1项横断面,2项比例对照,5项队列)进行系统综述,对其中的5项队列研究进行荟萃分析;
  • 5项队列研究共包括819,949名大于30岁的研究对象,随访10-26年不等,共记录15,961例结直肠癌;
  • 荟萃分析发现,DASH饮食与结直肠癌风险呈负相关,相对风险比为0.80(95% CI: 0.74-0.85);
  • 未发现研究间存在异质性,敏感性分析也未发现某一项研究显著影响了结果;
  • DASH饮食与结直肠癌的负相关在女性和男性中均存在。
flying dutchman
近期Clinical Nutrition发表了一项荟萃分析,该荟萃分析纳入5项队列研究,共计819,949名研究对象进行定量分析。分析发现,DASH饮食与结直肠癌风险呈负相关,且该相关性在男性和女性中均存在。

Adherence to the Dietary Approaches to Stop Hypertension (DASH) dietary pattern reduces the risk of colorectal cancer: A systematic review and meta-analysis



2020-02-07, Article

Abstract & Authors:展开

Background & aims: Colorectal cancer (CRC) has become a major concern due to industrialization and dietary changes generated by it. Many of the components of the DASH (Dietary Approach to Stop Hypertension) diet are associated with the risk of CRC. However, the relationship between DASH dietary pattern and CRC has not been studied yet in a systematic review and meta-analysis. The present study was conducted to review the studies investigating the relationship between DASH diet and the risk of CRC.
Methods: PubMed and Scopus search engines were searched to find relevant publications from inception up to September 2019. All the observational studies that addressed the association between DASH diet and CRC were included in the systematic review and meta-analysis. All the steps including data base search, screening, and data extraction were carried out by two researchers, independently.
Results: Eight studies included in this systematic review and 5 studies (out of 8 studies included in the systematic review) were included in the meta-analysis. Combining 12 effects sizes from 5 studies, a significant inverse association between adherence to the DASH diet and risk of CRC was found (RR: 0.80; 95% CI: 0.74, 0.85). Based on the result of this study, individuals with greater adherence to DASH diet had 20% lower risk of CRC.
Conclusion: The current study demonstrates that the risk of CRC is negatively associated with the adherence to the DASH dietary pattern.

First Authors:
Hadith Tangestania

Correspondence Authors:
Hadi Emamat

All Authors:
Hadith Tangestania,Asma Salari-Moghaddama,Hamid Ghalandari,Hadi Emamat