肠道菌群、肠道粘液和膳食纤维之间的互作(综述)
创作:大力 审核:szx 2020年11月01日
  • 组成膳食纤维的单糖高度多样化,粘液多糖由六种特定单糖组成,两者在结构(聚合、高度交联、被特定细菌降解)上有一定相似度;
  • 两者的底物可及性、菌群识别/结合策略、代谢方式均不同;
  • 两者与肠道菌群间的互作与肥胖、IBD、结直肠癌等疾病密切相关;
  • 肠道致病菌可结合并降解粘液多糖,粘液降解产物可调控致病菌的毒力基因;
  • 膳食纤维可通过直接(减少细胞粘附、抑制毒素结合等)与间接(调控菌群、抑制黏蛋白降解等)方式对抗致病菌。
主编推荐语
szx
膳食纤维与粘液多糖来源不同,但均不能被宿主的酶消化,只能由肠道菌群代谢。FEMS Microbiology Reviews上发表的一篇综述文章,详细介绍了膳食纤维与粘液多糖在结构、功能及代谢上的异同,重点概述了两者与肠道菌群的互作,及三者的互作与肥胖、IBD、结直肠癌等疾病的关联,并讨论了膳食纤维通过与粘液及菌群的互作以抑制致病菌感染的机制。
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Tripartite relationship between gut microbiota, intestinal mucus and dietary fibers: towards preventive strategies against enteric infections

肠道菌群、肠道粘液和膳食纤维的三方关系:针对肠道感染的预防策略

10.1093/femsre/fuaa052

2020-10-07, Review

Abstract & Authors:展开

Abstract:收起
The human gut is inhabited by a large variety of microorganims involved in many physiological processes and collectively refered as to gut microbiota. Disrupted microbiome has been associated with negative health outcomes and especially could promote the onset of enteric infections. To sustain their growth and persistence within the human digestive tract, gut microbes and enteric pathogens rely on two main polysaccharide compartments, namely dietary fibers and mucus carbohydrates. Several evidences suggest that the three-way relationship between gut microbiota, dietary fibers and mucus layer could unravel the capacity of enteric pathogens to colonize the human digestive tract and ultimately lead to infection. The review starts by shedding light on similarities and differences between dietary fibers and mucus carbohydrates structures and functions. Next, we provide an overview of the interactions of these two components with the third partner, namely the gut microbiota, under health and diseased situations. The review will then provide insights into the relevance of using dietary fibers interventions to prevent enteric infections with a focus on gut microbial imbalance and impaired-mucus integrity. Facing the numerous challenges in studying microbiota-pathogen-dietary fiber-mucus interactions, we lastly describe the characteristics and potentialities of currently available in vitro models of the human gut.

First Authors:
Sauvaitre Thomas

Correspondence Authors:
Blanquet-Diot Stéphanie

All Authors:
Sauvaitre Thomas,Etienne-Mesmin Lucie,Sivignon Adeline,Mosoni Pascale,Courtin Christophe,Van de Wiele Tom,Blanquet-Diot Stéphanie

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