女性儿童期经历虐待或提高机体慢性炎症水平
创作:Epi汪 审核:Epi汪 2019年10月18日
  • 纳入443名研究对象,平均年龄23.4岁,利用档案信息收集儿童期受到虐待的情况,比例为17%;
  • 但成年期自我报告的受到虐待的比例占5.4%~64.8%;
  • 检测儿童期收集到的干血斑样品中的C反应蛋白(CRP)水平;
  • 调整混杂因素之后,档案记录的女性儿童期虐待经历与CRP水平呈现正相关,尤其是经历肢体暴力的人;
  • 但男性个体中的关联无统计学意义,且自我回顾性报告的受虐经历与CRP水平无关;
  • 女性经历虐待或可增加慢性炎症状态的风险。
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Epi汪
本研究收集了儿童期医疗档案中记录的可推测的虐待经历,包括肢体暴力、性虐、忽视等问题,并在成年期回顾性调查了这些方面的内容,发现一致性并不高。通过与干血斑中CRP水平的分析,发现档案记录的信息与CRP的水平关联强度较大,尤其是在女性中,而回顾性报告的内容关联强度较弱。该研究提示,女性儿童经历虐待或增高机体慢性炎症水平,或将提高未来心血管疾病风险。
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Do documented records and retrospective reports of childhood maltreatment similarly predict chronic inflammation?

医疗记录和回顾性自我报告的儿童期虐待经历是否可以同等程度地预测慢性炎症的状态?

10.1017/S0033291719002575

2019-09-23, Article

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BACKGROUND: Childhood adversities have been associated with chronic inflammation and risk for cardiovascular disease. With some exceptions, existing knowledge of this relationship is based on retrospective self-reports, potentially subject to recall bias or memory problems. We seek to determine whether childhood maltreatment is associated with higher C-reactive protein (CRP) later in life and whether individuals with official and retrospective self-reports of maltreatment and men and women show similar increases in risk.
METHODS: Data are from in-person interviews in 2009-2010 with 443 offspring (mean age = 23.4) of parents in a longitudinal study of the consequences of childhood maltreatment. Official reports of maltreatment were abstracted from 2011-2013 Child Protective Services records. Eleven measures were used to assess self-reported maltreatment retrospectively. Seventeen percent of offspring had official reports, whereas self-reported prevalence rates ranged from 5.4% to 64.8%. CRP was assessed through blood spot samples. Regression models were used to estimate the effect of maltreatment on inflammation, adjusting for age, sex, race, parent occupational status, current depression, smoking, and heavy drinking.
RESULTS: Individuals with official reports of child maltreatment and, specifically, physical abuse, had significantly higher levels of CRP than non-maltreated individuals. Maltreated females showed elevated CRP, independent of control variables, whereas no significant association was observed in males. Retrospective self-report measures of child maltreatment did not predict elevated CRP.
CONCLUSIONS: Individuals with documented histories of childhood maltreatment are at increased risk for chronic inflammation and may benefit from targeted interventions. The results strengthen inferences about the effects of childhood maltreatment on inflammation in females.

First Authors:
Meg Osborn

Correspondence Authors:
Cathy Spatz Widom

All Authors:
Meg Osborn,Cathy Spatz Widom

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