提前添加固体辅食有助于婴儿睡眠
创作:花开 审核:周旸
  • 实验组(EIG)618名婴儿从3月龄开始,在摄取母乳的同时开始先后食用非过敏性和6种过敏性固体辅食,而对照组(SIG)607名婴儿按照英国婴儿喂养指南在出生后6个月内接受纯母乳喂养;
  • 与SIG组相比,EIG组婴儿的夜间睡眠时间显著延长,夜间觉醒次数减少;
  • 差异在婴儿6月龄时最为显著,EIG组婴儿每晚睡眠时间比SIG组长16.6分钟,觉醒次数由2.01减少至1.74;
  • 相比于EIG组,SIG组婴儿更频繁地表现出严重的睡眠问题,甚至影响母亲生活质量。
主编推荐语
周旸
尽管世界卫生组织建议在出生后半年内采用纯母乳喂养,许多家庭通过提前添加固体辅食来提高婴儿夜间睡眠质量。本研究对在英国采集的临床和跟踪数据进行二次分析,首次通过随机临床试验证实了提早添加固体辅食对婴儿睡眠的促进作用,对指导婴儿饮食、促进母婴健康均有参考价值,值得相关专业人士关注。
关键字
延伸阅读本研究的原文信息和链接出处,以及相关解读和评论文章。欢迎读者朋友们推荐!
图片
JAMA Pediatrics [IF:13.946]

Association of Early Introduction of Solids With Infant SleepA Secondary Analysis of a Randomized Clinical Trial

提前添加固体辅食与婴儿睡眠之间的关系:一项随机临床研究的二次分析

10.1001/jamapediatrics.2018.0739

2018-07-09, Article

Abstract & Authors:展开

Abstract:收起
Importance The World Health Organization recommends exclusive breastfeeding for 6 months. However, 75% of British mothers introduce solids before 5 months and 26% report infant waking at night as influencing this decision. Objective To determine whether early introduction of solids influences infant sleep. Design, Setting, and Participants The Enquiring About Tolerance study was a population-based randomized clinical trial conducted from January 15, 2008, to August 31, 2015, that included 1303 exclusively breastfed 3-month-old infants from England and Wales. Clinical visits took place at St Thomas’ Hospital, London, England, and the trial studied the early introduction of solids into the infant diet from age 3 months. Interventions The early introduction group (EIG) continued to breastfeed while nonallergenic and then 6 allergenic foods were introduced. The standard introduction group (SIG) followed British infant feeding guidelines (ie, exclusive breastfeeding to around age 6 months and to avoid any food consumption during this period). Main Outcomes and Measures Secondary analysis of an a priori secondary outcome of the effect of early food introduction on infant sleep using the standardized Brief Infant Sleep Questionnaire. Results Of the 1303 infants who were enrolled in the Enquiring About Tolerance study, 1225 participants (94%) completed the final 3-year questionnaire (618 SIG [95%] and 607 EIG [93%]). Randomization was effective and there were no significant baseline differences between the 2 groups. Following the early introduction of solids, infants in the EIG slept significantly longer and woke significantly less frequently than infants in the SIG. Differences between the 2 groups peaked at age 6 months. At this point, in the intention-to-treat analysis infants in the EIG slept for 16.6 (95% CI, 7.8-25.4) minutes longer per night and their night waking frequency had decreased from 2.01 to 1.74 wakings per night. Most clinically important, very serious sleep problems, which were significantly associated with maternal quality of life, were reported significantly more frequently in the SIG than in the EIG (odds ratio, 1.8; 95% CI, 1.22-2.61). Conclusions and Relevance In a randomized clinical trial, the early introduction of solids into the infant’s diet was associated with longer sleep duration, less frequent waking at night, and a reduction in reported very serious sleep problems. Trial Registration isrctn.org Identifier: ISRCTN14254740

First Authors:
Michael R Perkin

Correspondence Authors:
Gideon Lack

All Authors:
Michael R Perkin,Henry T Bahnson,Kirsty Logan,Tom Marrs,Suzana Radulovic,Joanna Craven,Carsten Flohr,Gideon Lack

评论