小婴儿早早添加牛奶饮食,好不好?(综述)
创作:Epi汪 审核:Epi汪 2019年12月20日
  • 检索相关文献,最终筛选纳入来自20个国家的45篇相关研究数据;
  • 总体的结果提示,婴儿早期引入牛奶或者牛奶配方奶粉,与随后的哮喘、喘息、湿疹/特异性皮炎等风险不存在统计学关联;
  • 少量的证据提示,在婴儿1个月内引入牛奶,会增加喘息的风险,3个月内引入牛奶饮食,会增加哮喘风险;
  • 目前关于在婴儿生命早期,尤其是3个月前,引入牛奶或者牛奶配方奶粉,是否会增加儿童特异性疾病风险的证据是匮乏的,亟需进一步的研究。
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Epi汪
有研究提示,婴儿过早摄入牛奶会增加随后发生特异性疾病,包括哮喘、湿疹等疾病的风险。本研究通过文献综述,提示这种关联的证据仍然匮乏,并且缺乏高质量的证据。
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Timing of Cow’s Milk or Cow’s Milk Formula Introduction to the Infant Diet and Atopic Risk in Children: a Systematic Review and Meta-analysis

将牛奶或者牛奶配方奶粉引入婴儿饮食的时间与儿童特异性疾病的风险的关联:系统综述和荟萃分析

10.1007/s12016-019-08770-9

2019-11-25, Article

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Infant feeding is an important early-life exposure that may influence the development of atopic disease. The optimal timing of introduction of food allergens, including cow’s milk (CM), is not known. This study aims to systematically review the evidence describing the effects of timing of CM or cow’s milk formula (CMF) introduction to the infant diet on the development of atopic diseases during childhood. Pubmed, Embase, CINAHL, Cochrane CENTRAL, and CNKI were searched through May 30, 2019. Study screening and data extraction by two reviewers followed the PRISMA statement. Data were extracted independently in duplicate, and meta-analyses were performed by pooling unadjusted and adjusted odds ratio (OR) separately. Heterogeneity was explored using I2 and publication bias by funnel plots and Begg’s tests. In total, 45 studies from 20 countries were included. Meta-analyses using adjusted data showed that no associations were observed between early introduction of CM or CMF and the risk of asthma (< 4 vs. ≥ 4 months: OR 1.16, 95% confidence interval (CI) 0.89, 1.51), wheeze (< 6 vs. ≥ 6 months: OR 1.15, 95% CI 0.85, 1.56), and eczema or atopic dermatitis (< 6 vs. ≥ 6 months: OR 0.96, 95% CI 0.65, 1.41). Overall, quite little high-quality evidence was identified to allow for definitive conclusions on the association between early CM or CMF introduction and risk of allergic diseases. Our meta-analysis on this topic highlights the specific gaps in information for public recommendations regarding CM or CMF feeding practice in an early stage of life, particularly before 3 months of age.

First Authors:
Mingyang Yuan

Correspondence Authors:
Kar Cheng

All Authors:
Mingyang Yuan,Miaoyu Tan,David Moore,Songying Shen,Xiu Qiu,G Neil Thomas,Kar Cheng

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