素食与美国心脏协会推荐饮食在冠状动脉疾病中的抗炎效应对比
创作:szx 审核:szx 2018年12月20日
  • 在一项纳入100名冠状动脉疾病患者的非盲随机试验中,患者分别进行素食或美国心脏协会推荐的饮食,持续干预8周;
  • 在校正了年龄、种族、基础腰围、糖尿病及与心肌梗死后,与美国心脏协会推荐的饮食相比,素食显著降低了高敏C反应蛋白的水平(降低了32%);
  • 两组饮食在BMI及腰围的减少上无显著差异,在血糖控制上也无显著差异;
  • 素食显著降低了13%的低密度脂蛋白胆固醇,但并未达到统计学显著性。
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szx
Journal of the American Heart Association上发表的一项最新饮食干预试验结果,对比了素食与美国心脏协会推荐饮食在冠状动脉疾病患者中的抗炎症作用,发现素食可更好地降低高敏C反应蛋白的水平。
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Anti‐Inflammatory Effects of a Vegan Diet Versus the American Heart Association–Recommended Diet in Coronary Artery Disease Trial

素食vs. 美国心脏协会推荐饮食在冠状动脉疾病试验中的抗炎症效应

10.1161/JAHA.118.011367

2018-10-30, Article

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Background: Dietary interventions may play a role in secondary cardiovascular prevention. hsCRP (High‐sensitivity C‐reactive protein) is a marker of risk for major adverse cardiovascular outcomes in coronary artery disease.
Methods and Results: The open‐label, blinded end‐point, EVADE CAD (Effects of a Vegan Versus the American Heart Association‐Recommended Diet in Coronary Artery Disease) trial randomized participants (n=100) with coronary artery disease to 8 weeks of a vegan or American Heart Association–recommended diet with provision of groceries, tools to measure dietary intake, and dietary counseling. The primary end point was high‐sensitivity C‐reactive protein. A linear regression model compared end points after 8 weeks of a vegan versus American Heart Association diet and adjusted for baseline concentration of the end point. Significance levels for the primary and secondary end points were set at 0.05 and 0.0015, respectively. A vegan diet resulted in a significant 32% lower high‐sensitivity C‐reactive protein (β, 0.68, 95% confidence interval [0.49–0.94]; P=0.02) when compared with the American Heart Association diet. Results were consistent after adjustment for age, race, baseline waist circumference, diabetes mellitus, and prior myocardial infarction (adjusted β, 0.67 [0.47–0.94], P=0.02). The degree of reduction in body mass index and waist circumference did not significantly differ between the 2 diet groups (adjusted β, 0.99 [0.97–1.00], P=0.10; and adjusted β, 1.00 [0.98–1.01], P=0.66, respectively). There were also no significant differences in markers of glycemic control between the 2 diet groups. There was a nonsignificant 13% reduction in low‐density lipoprotein cholesterol with the vegan diet when compared with the American Heart Association diet (adjusted β, 0.87 [0.78–0.97], P=0.01). There were no significant differences in other lipid parameters.
Conclusions: In patients with coronary artery disease on guideline‐directed medical therapy, a vegan diet may be considered to lower high‐sensitivity C‐reactive protein as a risk marker of adverse outcomes.

First Authors:
Binita Shah

Correspondence Authors:
Binita Shah

All Authors:
Binita Shah,Jonathan D Newman,Kathleen Woolf,Lisa Ganguzza,Yu Guo,Nicole Allen,Judy Zhong,Edward A Fisher,James Slater

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