Cell子刊:小肠菌群促进饮食脂质的消化吸收
  • 无菌小鼠抵抗高脂饮食诱导的肥胖,部分原因是小肠中脂肪的消化和吸收受损;
  • 小肠菌群通过促进小肠中脂肪酶活性、系统性调控肠内分泌信号和影响局部脂肪酸转运等机制,调控肠道上皮对脂质的消化和吸收;
  • 高脂饮食影响小肠菌群结构,给无菌小鼠定殖高脂饮食诱导的空肠菌群,即使食用低脂食物,其脂质吸收也增加;
  • 体内和体外实验表明,特定菌株(双酶梭菌C. bifermentans等)及其活性代谢物可增加小肠中与脂质吸收相关的Dgat2基因表达。
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mildbreeze
Cell Host and Microbe[IF:14.946]发表的最新研究表明,小肠菌群是饮食信号的关键转化者,促进宿主对脂质的消化和吸收。高脂饮食诱导的空肠菌群,可直接促进肠粘膜的脂质吸收,对营养过度和营养不良有潜在影响。这些发现或能为治疗肥胖带来启示。
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Small Intestine Microbiota Regulate Host Digestive and Absorptive Adaptive Responses to Dietary Lipids

小肠菌群调控宿主对饮食脂质消化吸收的适应性反应

10.1016/j.chom.2018.03.011

2018-04-11, Article

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The gut microbiota play important roles in lipid metabolism and absorption. However, the contribution of the small bowel microbiota of mammals to these diet-microbe interactions remains unclear. We determine that germ-free (GF) mice are resistant to diet-induced obesity and malabsorb fat with specifically impaired lipid digestion and absorption within the small intestine. Small bowel microbes are essential for host adaptation to dietary lipid changes by regulating gut epithelial processes involved in their digestion and absorption. In addition, GF mice conventionalized with high-fat diet-induced jejunal microbiota exhibit increased lipid absorption even when fed a low-fat diet. Conditioned media from specific bacterial strains directly upregulate lipid absorption genes in murine proximal small intestinal epithelial organoids. These findings indicate that proximal gut microbiota play key roles in host adaptability to dietary lipid variations through mechanisms involving both the digestive and absorptive phases and that these functions may contribute to conditions of over- and undernutrition.

First Authors:
Kristina Martinez-Guryn

Correspondence Authors:
Eugene Chang

All Authors:
Kristina Martinez-Guryn,Nathaniel Hubert,Katya Frazier,Saskia Urlass,Mark W Musch,Patricia Ojeda,Joseph F Pierre,Jun Miyoshi,Timothy J Sontag,Candace M Cham,Catherine A Reardon,Vanessa Leone,Eugene Chang

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