双相障碍患者的肠道菌群变化(综述)
创作:szx 审核:szx 02月18日
  • 纳入13项研究进行系统性综述,总结双相障碍与肠道菌群的关联;
  • 在5项相关研究中,有4项报道了双相障碍患者的肠道菌群α-多样性显著低于健康对照;
  • 在4项研究中发现,与健康对照相比,双相障碍患者的肠道菌群中,一个产丁酸盐分枝(包括瘤胃球菌科、粪杆菌属及柔嫩梭菌)的丰度发生变化,其中3项研究报道了其丰度的降低,而1项研究报道了其丰度的升高;
  • 2项研究报道了BD患者中的拟杆菌属及普氏菌属富集,而1项研究的结论与之相反。
主编推荐语
szx
Bipolar Disorders上发表的一篇系统性综述文章,总结了13项研究的结果以分析双相障碍患者的肠道菌群变化:多数研究报道了双相障碍患者的肠道菌群α-多样性降低,而部分研究报道了双相障碍患者的肠道菌群组成失调,以粪杆菌属(产丁酸盐菌)的减少及拟杆菌属的富集为特征。
关键字
延伸阅读本研究的原文信息和链接出处,以及相关解读和评论文章。欢迎读者朋友们推荐!
图片

Bipolar Disorder and the Gut Microbiome: a Systematic Review

双相障碍与肠道菌群:系统性综述

10.1111/bdi.13049

01-29, Review

Abstract & Authors:展开

Abstract:收起
Objectives: The microbiome is a rapidly advancing biomedical frontier with relevance for psychiatric illness. The gut microbiota interact with the central nervous system bidirectionally through the gut–brain axis and generate substances that may influence host metabolism, including short‐chain fatty acids such as butyrate. Understanding gut microbiota in bipolar disorder (BD) may suggest new disease markers and treatment approaches.
Methods: A PubMed search was performed on January 7, 2020 using terms "bipolar AND (microbiome OR microbiota)”, for articles in English in which the study population included a distinct BD group and the gut microbiota/microbiome was assessed.
Results: Thirteen articles met the inclusion criteria. In four out of five studies that reported on group comparisons with respect to diversity, lower α‐diversity was observed in BD relative to healthy controls (HC). The most convergent taxonomic finding was that in four studies, one particular clade distinguished gut microbiota between BD and HC: family Ruminococcaceae, genus Faecalibacterium, and species Faecalibacterium prausnitzii. Members of this clade, known for butyrate production, were reduced in BD relative to HC in three studies but elevated in a fourth. Additionally, genera Bacteroides or Bacteroides–Prevotella group species were elevated in BD in two studies but lower in a third.
Conclusions: Despite few studies and modest sample sizes, salient findings suggest that low α‐diversity and dysbiosis with respect to abundance of Faecalibacterium and Bacteroides may characterize BD in both a trait and state‐dependent fashion. Decreased richness and butyrate production also foster inflammation, which may be a hitherto unrecognized part of the pathophysiology underlying BD.

First Authors:
M Elizabeth Sublette

Correspondence Authors:
M Elizabeth Sublette

All Authors:
M Elizabeth Sublette,Stephanie Cheung,Evan Lieberman,Shoahua Hu,J John Mann,Anne‐Catrin Uhlemann,Jeffrey M Miller

评论