欲建母婴长期队列?看看新加坡经验
创作:尹小甜 审核:Epi汪 2020年12月11日
  • 新加坡S-PRESTO队列从2015年开始,现共入组1039名包含华裔、马来西亚裔、印度裔的18-45岁备孕夫妻1039对;
  • 备孕期共进行3次随访,如果12个月未妊娠,则结束随访,共有475名女性成功妊娠;
  • 妊娠期女性在孕期随访6次,新生儿出生后随访10次,目前至3岁;
  • 关注孕前、孕中及产后的营养、生活方式、母亲情绪对后代胎儿生长、表观基因组、代谢及神经表型、临床疾病的关联;
  • 收集包括血、尿、粪、皮肤贴片、上皮拭子等的多阶段多种生物样本。
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Epi汪
国内建立的母婴队列甚多,但是在每个队列中多多少少存在各种局限性。本文阐述了新加坡建立的孕前健康随访队列(S-PRESTO),其从孕前开始入组,一直随访到儿童出生后几年。在不同的阶段采集并随访不同的标本和内容,可做的研究相当丰富。目前也已经产出一系列的科研成果。由于新加坡地区的特殊性,其研究针对的3种人(华裔、马来西亚裔、印度裔)占据了世界上50%的人,具有较好的推广价值。在文末,团队也提供了合作的联系方式,实为一项优秀的队列研究,值得我们参考借鉴。
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Cohort profile: Singapore Preconception Study of Long-Term Maternal and Child Outcomes (S-PRESTO)

队列介绍:新加坡长期母婴健康孕前队列(S-PRESTO)

10.1007/s10654-020-00697-2

2020-11-21, Article

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The Singapore Preconception Study of Long-Term Maternal and Child Outcomes (S-PRESTO) is a preconception, longitudinal cohort study that aims to study the effects of nutrition, lifestyle, and maternal mood prior to and during pregnancy on the epigenome of the offspring and clinically important outcomes including duration of gestation, fetal growth, metabolic and neural phenotypes in the offspring. Between February 2015 and October 2017, the S-PRESTO study recruited 1039 Chinese, Malay or Indian (or any combinations thereof) women aged 18-45 years and who intended to get pregnant and deliver in Singapore, resulting in 1032 unique participants and 373 children born in the cohort. The participants were followed up for 3 visits during the preconception phase and censored at 12 months of follow up if pregnancy was not achieved (N = 557 censored). Women who successfully conceived (N = 475) were characterised at gestational weeks 6-8, 11-13, 18-21, 24-26, 27-28 and 34-36. Follow up of their index offspring (N = 373 singletons) is on-going at birth, 1, 3 and 6 weeks, 3, 6, 12, 18, 24 and 36 months and beyond. Women are also being followed up post-delivery. Data is collected via interviewer-administered questionnaires, metabolic imaging (magnetic resonance imaging), standardized anthropometric measurements and collection of diverse specimens, i.e. blood, urine, buccal smear, stool, skin tapes, epithelial swabs at numerous timepoints. S-PRESTO has extensive repeated data collected which include genetic and epigenetic sampling from preconception which is unique in mother-offspring epidemiological cohorts. This enables prospective assessment of a wide array of potential determinants of future health outcomes in women from preconception to post-delivery and in their offspring across the earliest development from embryonic stages into early childhood. In addition, the S-PRESTO study draws from the three major Asian ethnic groups that represent 50% of the global population, increasing the relevance of its findings to global efforts to address non-communicable diseases.

First Authors:
Evelyn Xiu Ling Loo,Shu-E Soh

Correspondence Authors:
Evelyn Xiu Ling Loo

All Authors:
Evelyn Xiu Ling Loo,Shu-E Soh,See Ling Loy,Sharon Ng,Mya Thway Tint,Shiao-Yng Chan,Jonathan Yinhao Huang,Fabian Yap,Kok Hian Tan,Bernard S M Chern,Heng Hao Tan,Michael J Meaney,Neerja Karnani,Keith M Godfrey,Yung Seng Lee,Jerry Kok Yen Chan,Peter D Gluckman,Yap-Seng Chong,Lynette Pei-Chi Shek,Johan G Eriksson,,Airu Chia,Anna Magdalena Fogel,Anne Eng Neo Goh,Anne Hin Yee Chu,Anne Rifkin-Graboi,Anqi Qiu,Bee Wah Lee,Bobby Kyungbeom Cheon,Candida Vaz,Christiani Jeyakumar Henry,Ciaran Gerard Forde,Claudia Chi,Dawn Xin Ping Koh,Desiree Y Phua,Doris Ngiuk Lan Loh,Elaine Phaik Ling Quah,Elizabeth Huiwen Tham,Evelyn Chung Ning Law,Faidon Magkos,Falk Mueller-Riemenschneider,George Seow Heong Yeo,Hannah Ee Juen Yong,Helen Yu Chen,Heng Hao Tan,Hong Pan,Hugo P S van Bever,Hui Min Tan,Izzuddin Bin Mohd Aris,Jeannie Tay,Jerry Kok Yen Chan,Jia Xu,Joanne Su-Yin Yoong,Johan Gunnar Eriksson,Jonathan Tze Liang Choo,Jonathan Y Bernard,Jonathan Yinhao Huang,Jun Shi Lai,Karen Mei Ling Tan,Keith M Godfrey,Kenneth Yung Chiang Kwek,Keri McCrickerd,Kothandaraman Narasimhan,Kok Wee Chong,Kuan Jin Lee,Li Chen,Lieng Hsi Ling,Ling-Wei Chen,Lourdes Mary Daniel,Lynette Pei-Chi Shek,Marielle V Fortier,Mary Foong-Fong Chong,Mei Chien Chua,Melvin Khee-Shing Leow,Michelle Zhi Ling Kee,Min Gong,Mya Thway Tint,Navin Michael,Ngee Lek,Oon Hoe Teoh,Priti Mishra,Queenie Ling Jun Li,Sambasivam Sendhil Velan,Seng Bin Ang,Shirong Cai,Si Hui Goh,Sok Bee Lim,Stella Tsotsi,Stephen Chin-Ying Hsu,Sue-Anne Ee Shiow Toh,Suresh Anand Sadananthan,Teng Hong Tan,Tong Wei Yew,Varsha Gupta,Victor Samuel Rajadurai,Wee Meng Han,Wei Wei Pang,Wen Lun Yuan,Yanan Zhu,Yin Bun Cheung,Yiong Huak Chan,Zai Ru Cheng

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