阴道菌群研究,恒河猴模型或可助力
创作:尹小甜 审核:Epi汪 06月11日
  • 纳入16只雌性恒河猴,进行纵向的阴道菌群检测,发现其显示出人类细菌性阴道炎的症状(Nugent评分>7分、线索细胞阳性、pH≥6等);
  • 给予恒河猴阴道内蔗糖凝胶治疗,并不会改变其阴道菌群;
  • 总体来说,其阴道菌群表现出普氏菌、卟啉单胞菌属、纤毛菌属、动弯杆菌属等丰度较高,与人类无症状/有症状的细菌性阴道炎菌群类似;
  • 未发现体内雌二醇水平与阴道菌群的关联;
  • 宏基因组测序显示恒河猴的阴道菌群结构和功能与人类都很相似。
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Epi汪
本研究通过对雌性恒河猴的阴道菌群纵向的研究,全面揭示了恒河猴阴道菌群的特点,并将其与人类阴道菌群进行比较。本研究为进一步开发利用恒河猴模型进行阴道菌群干预研究提供了基础。
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mSystems [IF:6.496]

Longitudinal Profiling of the Macaque Vaginal Microbiome Reveals Similarities to Diverse Human Vaginal Communities

恒河猴阴道菌群纵向图谱揭示了其与人类多样的阴道菌群的相似性

10.1128/mSystems.01322-20

04-27, Article

Abstract & Authors:展开

Abstract:收起
The vaginal microbiota plays an important role in women’s reproductive and urogenital health. It is now well accepted that a “healthy” vaginal microbiome is dominated by Lactobacillus species. Disturbances in this microbial community can lead to several adverse outcomes, including pelvic inflammatory disease and bacterial vaginosis (BV), as well as increased susceptibility to sexually transmitted infections, miscarriage, and preterm births. However, vaginal communities, especially those of women in the developing world, can be comprised of a diverse set of microorganisms in the absence of overt clinical symptoms. The implications of these diverse vaginal microbiomes for women’s health remain poorly understood. Rhesus macaques are an excellent translational animal model to address these questions due to significant physiological and genetic homology with humans. In this study, we performed a longitudinal analysis of clinical and microbiome data from 16 reproductive-age female rhesus macaques. At both the taxonomic and functional levels, the rhesus macaque vaginal microbiome was most similar to that of women who harbor a diverse vaginal community associated with asymptomatic/symptomatic bacterial vaginosis. Specifically, rhesus macaque vaginal microbiomes harbored a diverse set of anaerobic Gram-negative bacteria, including Sneathia, Prevotella, Porphyromonas, and Mobiluncus. Interestingly, some animals were transiently colonized by Lactobacillus and some with Gardnerella. Our in-depth and comprehensive analysis highlights the importance of the model to understand the health implications of a diverse vaginal microbiome and test interventions for manipulating this community.

First Authors:
Nicholas S Rhoades,Sara M Hendrickson

Correspondence Authors:
Mark K Slifka,Ilhem Messaoudia

All Authors:
Nicholas S Rhoades,Sara M Hendrickson,Danielle R Gerken,Kassandra Martinez,Ov D Slayden,Mark K Slifka,Ilhem Messaoudia

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