羟基肉桂酸对肠道菌群及健康的影响(综述)
创作:szx 审核:szx 01月24日
  • HCA在人体内可通过3种途径代谢:完整吸收、小肠/肝脏酶催化下的硫酸化等修饰、肠道菌群代谢;
  • 结合状态下的HCA可能促进肠道有益菌的生长,抑制致病菌生长,游离HCA可能保护肠道屏障并促进肠道损伤愈合;
  • HCA可能通过调节肠道菌群,缓解动物模型的IBD、肠道缺血再灌注损伤、结直肠癌等疾病;
  • 饮食中的碳水化合物、脂质、蛋白质、微量营养素、植物化学物质及食物加工过程可影响HCA的生物利用度;
  • 过量摄入HCA有潜在的促氧化及致癌风险。
主编推荐语
szx
羟基肉桂酸(HCA)是酚酸中的主要种类之一,通常与植物细胞壁呈结合状态,只能被有限的几种酶解离。HCA包含的种类包括:咖啡酸、阿魏酸、芥子酸及香豆酸。Comprehensive Reviews in Food Science and Food Safety上发表的一篇综述文章,详细介绍了各类HCA在人体内的吸收及代谢途径,重点概述了肠道菌群对HCA的代谢,并总结了各类HCA对肠道菌群组成及功能的调节作用,以及在动物模型及细胞系中HCA对IBD等多种疾病的潜在改善作用。
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Hydroxycinnamic acids on gut microbiota and health

羟基肉桂酸对肠道菌群及健康的影响

10.1111/1541-4337.12663

2020-10-30, Article

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Hydroxycinnamic acids (HCAs) are a major class of phenolic acids with the characteristic phenylpropanoid C6‐C3 backbone. Its typically conjugated status with plant cell wall components and liberation by limited enzymes might be the reason for its neglect by researchers compared to flavonoid‐type polyphenols. The polyphenol–gut microbiota interactions and their impact on human health have captured the interest of researchers recently. In addition, there has been a significant progress over the past few years in understanding the gut microbiota‐modulating effect of HCA using animal model studies. This review discusses the metabolism of HCA in the digestive tract, HCA–gut microbiota interactions, and its link to colorectal cancer, inflammatory bowel diseases, mental‐cognitive impairments, nonalcoholic liver disease, and obesity. The effects of food matrix and processing technologies on HCA bioavailability and HCA–gut microbiota interactions, and HCA safety concerns are also featured in this review. This paper has provided an in‐depth insight on HCA–gut microbiota relationship and identified the current literature gaps for future research.

First Authors:
William Leonard

Correspondence Authors:
Zhongxiang Fang

All Authors:
William Leonard,Pangzhen Zhang,Danyang Ying,Zhongxiang Fang

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