Cell:抗生素治疗后,益生菌干预不利于菌群复原
  • 在小鼠和健康受试者中,分析混合益生菌干预和自体粪菌移植(aFMT)如何影响抗生素扰动后的肠道菌群和肠转录组恢复;
  • 抗生素显著促进了人益生菌在人体肠粘膜的定殖,但该作用在小鼠中较轻;
  • 与无干预的自发性恢复相比,益生菌明显推迟了宿主的粪便和肠粘膜菌群的重建及宿主转录组的恢复,且使其难以完全复原;
  • 而aFMT可使菌群和人体肠转录组在几天内近乎完全复原;
  • 体外实验中,益生菌诱导的菌群抑制作用与乳杆菌属分泌的可溶因子有关。
主编推荐语
mildbreeze
抗生素治疗后常用益生菌来调理菌群失调,但尚不清楚该过程中益生菌在肠粘膜菌群重建中扮演什么角色。Cell刚刚发表来自以色列魏茨曼研究所两位Eran等主导的另一项研究,表明抗生素治疗后的益生菌干预,并不利于肠粘膜菌群和肠道基因表达的复原,而自体粪菌移植(aFMT)可使其快速恢复。这些发现提示,aFMT或个性化益生菌干预,应是抗生素后促进菌群复原的更佳方法。
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Cell [IF:66.85]

Post-Antibiotic Gut Mucosal Microbiome Reconstitution Is Impaired by Probiotics and Improved by Autologous FMT

抗生素后的肠粘膜菌群重建被益生菌损害、被自体FMT改善

10.1016/j.cell.2018.08.047

2018-09-06, Article

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Probiotics are widely prescribed for prevention of antibiotics-associated dysbiosis and related adverse effects. However, probiotic impact on post-antibiotic reconstitution of the gut mucosal host-microbiome niche remains elusive. We invasively examined the effects of multi-strain probiotics or autologous fecal microbiome transplantation (aFMT) on post-antibiotic reconstitution of the murine and human mucosal microbiome niche. Contrary to homeostasis, antibiotic perturbation enhanced probiotics colonization in the human mucosa but only mildly improved colonization in mice. Compared to spontaneous post-antibiotic recovery, probiotics induced a markedly delayed and persistently incomplete indigenous stool/mucosal microbiome reconstitution and host transcriptome recovery toward homeostatic configuration, while aFMT induced a rapid and near-complete recovery within days of administration. In vitro, Lactobacillus-secreted soluble factors contributed to probiotics-induced microbiome inhibition. Collectively, potential post-antibiotic probiotic benefits may be offset by a compromised gut mucosal recovery, highlighting a need of developing aFMT or personalized probiotic approaches achieving mucosal protection without compromising microbiome recolonization in the antibiotics-perturbed host.

First Authors:
Jotham Suez,Niv Zmora,Gili Zilberman-Schapira,Uria Mor

Correspondence Authors:
Zamir Halpern,Eran Segal,Eran Elinav

All Authors:
Jotham Suez,Niv Zmora,Gili Zilberman-Schapira,Uria Mor,Mally Dori-Bachash,Stavros Bashiardes,Maya Zur,Dana Regev-Lehavi,Rotem Ben-Zeev Brik,Sara Federici,Max Horn,Yotam Cohen,Andreas E Moor,David Zeevi,Tal Korem,Eran Kotler,Alon Harmelin,Shalev Itzkovitz,Nitsan Maharshak,Oren Shibolet,Meirav Pevsner-Fischer,Hagit Shapiro,Itai Sharon,Zamir Halpern,Eran Segal,Eran Elinav

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