Nature综述:脂肪肝中,肠道菌群到底起何作用?
  • 非酒精性脂肪肝(NAFLD)与代谢综合征、菌群失调、不良饮食、肠道健康状态有关;
  • 菌群失调可促进NAFLD的病理过程;
  • 菌群失调导致肠道对细菌代谢产物的通透性增加,使肝脏接触到更多有害物质,炎症和纤维化加重;
  • 菌群失调加不良饮食,可改变肠腔内食物的代谢,如特定短链脂肪酸、酒精的生成增加,胆碱水平降低,进而导致肠动力、炎症和其他免疫变化,促进肝损伤;
  • 特定食物成分和生活方式能够影响NAFLD的发生发展,并与菌群改变有关。
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蓝灿辉 | 热心肠先生
Nature Reviews Gastroenterology & Hepatology最近一篇关于非酒精性脂肪肝中肠道菌群角色的综述,值得一读。
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The role of the gut microbiota in NAFLD

肠道菌群在非酒精性脂肪肝中的作用

10.1038/nrgastro.2016.85

2016-06-08, Review

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NAFLD is now the most common cause of liver disease in Western countries. This Review explores the links between NAFLD, the metabolic syndrome, dysbiosis, poor diet and gut health. Animal studies in which the gut microbiota are manipulated, and observational studies in patients with NAFLD, have provided considerable evidence that dysbiosis contributes to the pathogenesis of NAFLD. Dysbiosis increases gut permeability to bacterial products and increases hepatic exposure to injurious substances that increase hepatic inflammation and fibrosis. Dysbiosis, combined with poor diet, also changes luminal metabolism of food substrates, such as increased production of certain short-chain fatty acids and alcohol, and depletion of choline. Changes to the microbiome can also cause dysmotility, gut inflammation and other immunological changes in the gut that might contribute to liver injury. Evidence also suggests that certain food components and lifestyle factors, which are known to influence the severity of NAFLD, do so at least in part by changing the gut microbiota. Improved methods of analysis of the gut microbiome, and greater understanding of interactions between dysbiosis, diet, environmental factors and their effects on the gut-liver axis should improve the treatment of this common liver disease and its associated disorders.

First Authors:
Christopher Leung

Correspondence Authors:
Christopher Leung

All Authors:
Christopher Leung,Leni Rivera,John B Furness,Peter W Angus

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