膳食纤维调节小肠中的颗粒聚集
创作:女巫 审核:szx 2019年02月13日
  • 小肠腔充满微生物、治疗性颗粒和食物颗粒等微粒,这种颗粒悬浮液的结构可能影响药物和营养素的摄取以及肠道菌群的功能;
  • 颗粒在离体的小肠腔内液体中自发聚集,而这种聚集无需粘蛋白和免疫球蛋白;
  • 可使用膳食纤维中的聚合物调控小肠中颗粒的聚集,不需要特定的化学相互作用;
  • 颗粒的聚集是可调节的,通过给小鼠喂食不同分子量的膳食纤维,可控制小肠腔液中的颗粒聚集。
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eLife上发表的一项最新研究,发现膳食纤维中的高分子聚合物可调节小肠中的颗粒聚集。
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eLife [IF:7.08]

High-molecular-weight polymers from dietary fiber drive aggregation of particulates in the murine small intestine

膳食纤维中的高分子量聚合物驱动小鼠小肠中颗粒的聚集

10.7554/eLife.40387

2019-01-22, Article

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Abstract:收起
The lumen of the small intestine (SI) is filled with particulates: microbes, therapeutic particles, and food granules. The structure of this particulate suspension could impact uptake of drugs and nutrients and the function of microorganisms; however, little is understood about how this suspension is re-structured as it transits the gut. Here, we demonstrate that particles spontaneously aggregate in SI luminal fluid ex vivo. We find that mucins and immunoglobulins are not required for aggregation. Instead, aggregation can be controlled using polymers from dietary fiber in a manner that is qualitatively consistent with polymer-induced depletion interactions, which do not require specific chemical interactions. Furthermore, we find that aggregation is tunable; by feeding mice dietary fibers of different molecular weights, we can control aggregation in SI luminal fluid. This work suggests that the molecular weight and concentration of dietary polymers play an underappreciated role in shaping the physicochemical environment of the gut.
Editorial note: This article has been through an editorial process in which the authors decide how to respond to the issues raised during peer review. The Reviewing Editor's assessment is that all the issues have been addressed (see decision letter).

First Authors:
Asher Preska Steinberg

Correspondence Authors:
Rustem F Ismagilov

All Authors:
Asher Preska Steinberg,Sujit S Datta,Thomas Naragon,Justin C Rolando,Said R Bogatyrev,Rustem F Ismagilov

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