肠道菌群组成、功能及耐药组主要受生活方式影响
创作:aluba 审核:aluba 2020年03月27日
  • 通过对比人、圈养黑猩猩及大猩猩、野生黑猩猩及大猩猩的肠道菌群,发现相比于地理因素,肠道菌群的分类群组成更多地受到宿主生活方式的影响;
  • 菌群的功能通路及耐药组也主要受到宿主生活方式的影响;
  • 相比于野生黑猩猩及大猩猩,圈养黑猩猩及大猩猩的抗生素耐药基因丰度(abundance)及丰富度(richness)均显著升高;
  • 通过功能宏基因组分析,鉴定出一系列新型抗生素耐药基因,包括对粘菌素(对抗耐药菌的最后手段之一)的耐药基因。
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aluba
通过对比不同生活方式下、不同地理区域中的相近物种,可分析宿主生活方式、地理因素及宿主物种对肠道菌群的影响。ISME Journal上发表的一项最新研究,通过对比生活在刚果的野生黑猩猩及大猩猩、生活在野生动物附近的刚果人、生活在美国的圈养黑猩猩及大猩猩的肠道菌群,发现相比于地理因素,菌群的组成、功能及耐药组受到生活方式的影响更大。同时,该研究鉴定出了一系列新的抗生素耐药基因。
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ISME Journal [IF:11.217]

The microbiome and resistome of chimpanzees, gorillas, and humans across host lifestyle and geography

黑猩猩、大猩猩和人类中跨越宿主生活方式和地理的菌群和耐药组

10.1038/s41396-020-0634-2

2020-03-20, Article

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The gut microbiome can vary across differences in host lifestyle, geography, and host species. By comparing closely related host species across varying lifestyles and geography, we can evaluate the relative contributions of these factors in structuring the composition and functions of the microbiome. Here we show that the gut microbial taxa, microbial gene family composition, and resistomes of great apes and humans are more related by host lifestyle than geography. We show that captive chimpanzees and gorillas are enriched for microbial genera commonly found in non-Westernized humans. Captive ape microbiomes also had up to ~34-fold higher abundance and up to ~5-fold higher richness of all antibiotic resistance genes compared with wild apes. Through functional metagenomics, we identified a number of novel antibiotic resistance genes, including a gene conferring resistance to colistin, an antibiotic of last resort. Finally, by comparing our study cohorts to human and ape gut microbiomes from a diverse range of environments and lifestyles, we find that the influence of host lifestyle is robust to various geographic locations.

First Authors:
Tayte P Campbell

Correspondence Authors:
Gautam Dantas

All Authors:
Tayte P Campbell,Xiaoqing Sun,Vishal H Patel,Crickette Sanz,David Morgan,Gautam Dantas

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