湖南师大等:乙醇胺调节菌群改善断奶大鼠的肠道功能
  • 断奶大鼠随机分组并以不同浓度的乙醇胺(Etn)饮用水干预2周;
  • 相比对照组,500μm Etn可显著提高大鼠空肠超氧化物歧化酶和谷胱甘肽过氧化物酶水平,证明其粘膜抗氧化能力增加;
  • Etn可改变大鼠拟杆菌门、变形菌门、Elusimicrobia和柔膜菌门丰度,500μm Etn导致产生的结肠菌群有利于糖、脂相关的代谢和生物合成;
  • Etn>250μm时,厌氧菌数量和抗氧化胁迫发生改变;
  • 母乳中含有Etn,或是母乳喂养促进婴儿肠道健康的较好解释。
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母乳中的乙醇胺是磷脂酰乙醇胺,后者对于肠道菌群维持及肠道发育十分重要。湖南师范大学和中科院亚热带农业生态所团队共同主导的研究,在British Journal of Nutrition发表,揭示了乙醇胺显著改善断奶大鼠的肠道菌群组成、提升肠道功能。
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Ethanolamine enhances intestinal functions by altering gut microbiome and mucosal anti-stress capacity in weaned rats

乙醇胺通过调节断奶大鼠肠道菌群和黏膜抗应激能力来增强肠道功能

10.1017/S0007114518001101

2018-05-23, Article

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Ethanolamine (Etn) contained in milk is the base constituent of phosphatidylethanolamine and is required for the proliferation of intestinal epithelial cells and bacteria, which is important for maintenance of the gut microbiome and intestinal development. The present study investigated the effect of Etn on intestinal function and microbiome using 21-d-old Sprague-Dawley rats treated with 0, 250, 500 and 1000 μm Etn in drinking water for 2 weeks immediately after weaning. Growth performance, intestinal morphology, antioxidant capacity and mucosal immunity, as well as gut microbiota community composition, were evaluated. Metagenomic prediction and metabolic phenotype analysis based on 16S RNA sequencing were also carried out to assess changes in metabolic functions. We found that weaned rats administered 500 μm Etn enhanced mucosal antioxidant capacity, as evidenced by higher superoxide dismutase and glutathione peroxidase levels in the jejunum (P<0·05) compared with those in the control group. Predominant microbes including Bacteroidetes, Proteobacteria, Elusimicrobia and Tenericutes were altered by different levels of Etn compared with the control group. An Etn concentration of 500 µm shifted colonic microbial metabolic functions that are in favour of lipid- and sugar-related metabolism and biosynthesis. Etn also altered the metabolic phenotypes such as anaerobic microbial counts, and oxidative stress tolerance at over 250 µm. This is the first report for a role of Etn in modifying gut microbiota and intestinal functions. Our findings highlighted the important role of Etn in shaping gut microbial community and promotes intestinal functions, which may provide a better insight of breast-feeding to infant's gut health.

First Authors:
Jian Zhou

Correspondence Authors:
Xia Xiong,Yulong Yin

All Authors:
Jian Zhou,Xia Xiong,Ke-Xing Wang,Li-Jun Zou,Peng Ji,Yulong Yin

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