华中农大:母猪围产期的代谢综合征与肠道菌群变化
  • 分析长白母猪在妊娠30、109天和分娩后3、14天的粪便菌群,监测粪便与血液中的代谢标志物、肠道通透性与炎症反应;
  • 围产期母猪,尤其在泌乳早期,经历了包括胰岛素敏感性降低与低度炎性反应在内的代谢综合征;
  • 肠道菌群与代谢产物在围产期发生剧烈变化,泌乳早期变形菌门和梭杆菌门增加,菌群丰富度、丁酸产生菌和粪便丁酸含量减少;
  • 泌乳早期母猪肠道菌群的变化,导致肠道通透性与血浆内毒素增加,或与其代谢紊乱和炎症状态密切相关。
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Frontiers in Microbiology近期发表来自华中农业大学团队的研究,表明围产期母猪呈现出代谢紊乱和低度炎症的特征,与肠道菌群及代谢产物的改变有关。
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Metabolic Syndrome During Perinatal Period in Sows and the Link With Gut Microbiota and Metabolites

围产期母猪代谢综合征及其与肠道菌群和代谢产物的关联

10.3389/fmicb.2018.01989

2018-08-24, Article

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In humans, the metabolic and immune changes occurring during perinatal period also describe metabolic syndrome. Gut microbiota can cause symptoms of metabolic syndrome in pregnant women. Increased gut permeability is also involved in metabolic disorders in non-pregnant hosts. However, longitudinal studies investigating the changes in metabolic characteristics, gut microbiota, and gut permeability of sows throughout pregnancy and lactation are lacking. The correlation between gut microbiota and metabolic status of sows is also poorly known. The present study was conducted to investigate the temporal variations in sow metabolic characteristics, gut microbiota, gut permeability, and gut inflammation at days 30 (G30) and 109 (G109) of gestation and days 3 (L3) and 14 (L14) of lactation. Results showed that insulin sensitivity was decreased in L3. Circulating concentrations of pro-inflammatory cytokine IL-6 increased in G109 and L3. 16S rRNA gene sequencing of the V3-V4 region showed that gut microbiota changed dramatically across different reproductive stages. The bacterial abundance and alpha diversity in L3 were the lowest. The phyla and exhibited the highest relative abundance in L3. Among the genera, , , and were highest, but the lowest, in relative abundance in L3. The fecal levels of acetate and total short-chain fatty acids were increased in G109, but fecal butyrate concentrations were markedly decreased in L3. The plasma zonulin concentrations, a biomarker for gut permeability, were increased in G109 and L3. The plasma endotoxin concentrations were increased in L3. Furthermore, levels of fecal lipocalin-2 and pro-inflammatory cytokines IL-6 and TNF-α were increased in G109 and L3. In contrast, fecal levels of anti-inflammatory cytokine IL-10 were significantly decreased in G109 and L3. Additionally, the increased relative abundances of in L3 were positively correlated with plasma zonulin and fecal endotoxin but negatively correlated with fecal IL-10. These findings indicate that the mother sow exhibits a metabolic syndrome and dramatical changes in gut microbiota during perinatal period, especially in early lactation. Besides, increased gut permeability and plasma endotoxin concentrations caused by negative microbial changes would possibly be the potential mechanisms under which sow's metabolic disorders and inflammatory status were exacerbated during early lactation.

First Authors:
Chuanshang Cheng

Correspondence Authors:
Siwen Jiang,Jian Peng

All Authors:
Chuanshang Cheng,Hongkui Wei,Huichao Yu,Chuanhui Xu,Siwen Jiang,Jian Peng

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