单形拟杆菌+膳食纤维,可缓解小鼠肥胖
创作:圆滑的铁勺 审核:Vera 02月05日
  • 单形拟杆菌和麦麸提取物(WBE)单独干预可降低胆固醇血症和血糖等代谢改变,但均不具有抗肥胖作用;
  • 单形拟杆菌和WBE联合干预可降低饮食诱导的肥胖小鼠体重和肥胖;
  • 联合干预中细菌提高肝糖原合成,影响肠道脂质吸收等,从而改善能量代谢通路;
  • WBE促进具有抗炎性质的丁酸盐产生,而联合干预使增幅最大化,阻止了饮食诱导的肠道炎症转移;
  • 联合干预通过IL22信号通路改善全身炎症,修复肠道免疫稳态。
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Vera
肠道菌群是微生物治疗的靶点,Gut Microbes发表了一项研究,发现单形拟杆菌B.uniformis和麦麸提取物(WBE)联合治疗饮食诱导的肥胖小鼠模型,发现小鼠体重和肥胖表型有所缓解,胆固醇血症和血糖等有所改善,同时发现这些改善可能和有抗炎性质的丁酸盐的产生相关。
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Gut Microbes [IF:7.74]

Bacteroides uniformis combined with fiber amplifies metabolic and immune benefits in obese mice

单形拟杆菌与纤维组合增强肥胖小鼠代谢和免疫益处

10.1080/19490976.2020.1865706

01-26, Article

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Gut microbiota represents a therapeutic target for obesity. We hypothesize that B. uniformis CECT 7771 combined with wheat bran extract (WBE), its preferred carbon source, may exert superior anti-obesity effects. We performed a 17-week intervention in diet-induced obese mice receiving either B. uniformis, WBE, or their combination to identify interactions and independent actions on metabolism and immunity. B. uniformis combined with WBE was the most effective intervention, curbing weight gain and adiposity, while exerting more modest effects separately. The combination restored insulin-dependent metabolic routes in fat and liver, although the bacterium was the primary driver for improving whole-body glucose disposal. Moreover, B. uniformis-combined with WBE caused the highest increases in butyrate and restored the proportion of induced intraepithelial lymphocytes and type-3 innate lymphoid cells in the intestinal epithelium. Thus, strengthening the first line of immune defense against unhealthy diets and associated dysbiosis in the intestine. This intervention also attenuated the altered IL22 signaling and liver inflammation. Our study shows opportunities for employing B. uniformis, combined with WBE, to aid in the treatment of obesity.

First Authors:
Inmaculada López-Almela,Marina Romaní-Perez

Correspondence Authors:
Marina Romaní-Perez

All Authors:
Inmaculada López-Almela,Marina Romaní-Perez,Clara Bullich-Vilarrubias,Alfonso Benítez-Páez,Eva M Gómez Del Pulgar,Rubén Francés,Gerhard Liebisch,Yolanda Sanz

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