微生物组如何影响癌症进程和疗效?(观点)
  • 微生物组或通过影响血浆代谢物水平、中枢神经系统、机体奖励机制及对药物的反应等代谢途径间接影响癌症;
  • 定植于肿瘤组织或与原发瘤共同迁移至转移灶的共生菌或直接影响癌症进程和治疗,但机制尚不明确;
  • 了解微生物、免疫和癌症之间的复杂反馈,以及它们对免疫治疗的影响需要多学科方法和系统视角;
  • 放疗、化疗、骨髓移植等癌症治疗损害原有微生物组并导致各种并发症,因此癌症治疗后的微生物组重建对疗效的提高至关重要。
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Lexi
微生物组或影响癌症进展和治疗反应,但具体作用尚不清楚,需要更多的研究。最新发表在Trends in Cancer的观点文章详细分析了微生物组对癌症进程和治疗的直接或间接影响方式。微生物组与癌症之间的互作是两个复杂系统的互作,或需引入系统生物学的方法进行分析。目前已有一些改变恢复癌症患者微生物组的治疗方法正在进行试验,但仍需要进一步探究以更好地治疗癌症。
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Trends in Cancer [IF:11.093]

The Cancer Microbiome: Distinguishing Direct and Indirect Effects Requires a Systemic View

癌症与微生物组:区分直接和间接影响需要系统性视角

10.1016/j.trecan.2020.01.004

02-07, Review

Abstract & Authors:展开

Abstract:收起
The collection of microbes that live in and on the human body – the human microbiome – can impact on cancer initiation, progression, and response to therapy, including cancer immunotherapy. The mechanisms by which microbiomes impact on cancers can yield new diagnostics and treatments, but much remains unknown. The interactions between microbes, diet, host factors, drugs, and cell–cell interactions within the cancer itself likely involve intricate feedbacks, and no single component can explain all the behavior of the system. Understanding the role of host-associated microbial communities in cancer systems will require a multidisciplinary approach combining microbial ecology, immunology, cancer cell biology, and computational biology – a systems biology approach.

First Authors:
Joao B Xavier

Correspondence Authors:
Joao B Xavier

All Authors:
Joao B Xavier,Vincent B Young,Joseph Skufca,Fiona Ginty,Traci Testerman,Alexander T Pearson,Paul Macklin,Amir Mitchell,Ilya Shmulevich,Lei Xie,J Gregory Caporaso,Keith A Crandall,Nicole L Simone,Filipa Godoy-Vitorino,Timothy J Griffin,Katrine L Whiteson,Heather H Gustafson,Daniel J Slade,Thomas M Schmidt,Marina R S Walther-António,Tal Korem,Bobbie-Jo M Webb-Robertson,Mark P Styczynski,W Evan Johnson,Christian Jobin,Jason M Ridlon,Andrew Y Koh,Michael Yu,Libusha Kelly,Jennifer A Wargo

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